Abstract
Calcitriol has not been approved for the treatment of osteoporosis by the Food and Drug Administration. We do not claim that efficacy and safety have been demonstrated, but only that the findings are unclear enough to warrant continued investigation. For example, a recent two center, place-controlled study found that 3 years of treatment with calcitriol of women with postmenopausal osteoporosis resulted in a highly significant 65% reduction of vertebral fracture rate.