Abstract
Burn centers are often called upon to manage skin diseases other than burn injuries. These diseases are typically exfoliating skin diseases such toxic epidermal necrolysis syndrome and Stevens–Johnson syndrome, and necrotizing skin diseases such as necrotizing soft tissue infections, necrotizing fasciitis, and purpura fulminans. The unifying characteristic of these diseases is skin and soft tissue compromise and thus these patients are best managed in burn centers with expertise in wound care. This chapter reviews the etiology, pathogenesis, clinical manifestations, and treatment options for these diseases.