Abstract
Creatine supplements have a long history of use for improving muscle performance. While there are a number of studies that document the effects of creatine supplementation on muscle strength and performance, there are relatively few studies examining oral bioavailability. Despite early studies suggesting nearly complete oral absorption of creatine monohydrate, there are a number of findings that suggest that creatine absorption from the gastrointestinal tract is far from complete and that significant improvements in bioavailability can be obtained. This review examines the mechanisms controlling creatine absorption in the intestine and implications for improving the bioavailability of creatine supplements.