Abstract
This chapter discusses the prevention of type 2 diabetes. People at high risk of developing type 2 diabetes can often be identified with simple clinical tests. Many of the risk factors-such as obesity, physical inactivity, and subdiagnostic elevations in glycemia -that predict which of these people are most likely to develop diabetes are potentially modifiable. Randomized clinical trials have confirmed that treatment of diabetes risk factors in high-risk persons can reduce the development of new cases of diabetes. However, none of the tested interventions are fully successful at preventing diabetes, indicating that more effective interventions are needed. © 2011 by Oxford University Press. All rights reserved.