Evidence for a role for oligomerization in prestin

Richard Hallworth

doi:10.1063/1.5038500

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Evidence for a role for oligomerization in prestin

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Evidence for a role for oligomerization in prestin

Richard Hallworth

To the Ear and Back Again - Advances in Auditory Biophysics : Proceedings of the 13th Mechanics of Hearing Workshop, Vol.1965, 100002

AIP Conference Proceedings, 1965, American Institute of Physics Inc.

13th Mechanics of Hearing Workshop: To the Ear and Back Again - Advances in Auditory Biophysics, MoH 2017 (St. Catharines, Canada, 06/19/2017 - 06/24/2017)

05/31/2018

DOI: https://doi.org/10.1063/1.5038500

Abstract

Physics and Astronomy(all)

Clear evidence now points to mammalian prestin being a tetramer. Tetramerization is found to be ubiquitous in the Slc26a family, of which mammalian prestin is a member. However, no functional role for oligomerization has yet been found. I here show evidence that prestin oligomerization is possibly important for correct function.

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Title: Evidence for a role for oligomerization in prestin
Creators: Richard Hallworth (Author) - Department of Biomedical Sciences
Additional links: Bergevin, Christopher; Puria, Sunil; Piedmont, Ralph L.; Village, Andrew
Publication Details: To the Ear and Back Again - Advances in Auditory Biophysics : Proceedings of the 13th Mechanics of Hearing Workshop, Vol.1965, 100002
Conference: 13th Mechanics of Hearing Workshop: To the Ear and Back Again - Advances in Auditory Biophysics, MoH 2017 (St. Catharines, Canada, 06/19/2017 - 06/24/2017)
Series: AIP Conference Proceedings; 1965
Publisher: American Institute of Physics Inc.
Grant note: This study was funded by NIH P20GM103427 (NIGMS) and the Phillip E. Heflin Auditory Research Fund. I thank Michael Nichols, Sándor Lovas, Kirk Beisel, and Dominik Oliver for useful discussions.
Identifiers: 991005930348502656
Academic Unit: Biomedical Sciences
Language: English
Resource Type: Conference paper