A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

A. Christov; W. J. Kostuk; G. Jablonsky; P. Desjardins; R. Courtis; B. Jardine; A. Bailey; J. Odlum-Blair; J. Motiejunas; S. McConnell; A. Lucas

doi:10.1117/12.409327

Conference proceeding

A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

A. Christov, W. J. Kostuk, G. Jablonsky, P. Desjardins, R. Courtis, B. Jardine, A. Bailey, J. Odlum-Blair, J. Motiejunas, S. McConnell, …

Proceedings of SPIE - The International Society for Optical Engineering; Optical Biopsy and Tissue Optics, Vol.4161

2000

DOI: https://doi.org/10.1117/12.409327

Abstract

Angioplasty

Antiplatelet treatment

Membrane fluidity

Platelet activation

Bioassay

Calcium

Cardiology

Fluorescence

Light transmission

Anti-platelet treatment

Coronary artery angioplasty

Plasma membrane fluidity

Platelet aggregation

Biological materials

A method for simultaneous fluorescence spectroscopic measurement of surface membrane fluidity, platelet aggregation, and intracellular calcium concentration was developed. The capacity of the system to assess platelet activation associated with coronary artery angioplasty and anti-platelet treatment was confirmed. This approach offers a new analytical technique for circulating platelet activation.

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Title: A three tiered fluorescence-based system for monitoring activation-related changes in human platelets
Creators: A. Christov - University of Western States
W. J. Kostuk - London Health Sciences Centre
G. Jablonsky - London Health Sciences Centre
P. Desjardins - London Health Sciences Centre
R. Courtis - London Health Sciences Centre
B. Jardine - London Health Sciences Centre
A. Bailey - London Health Sciences Centre
J. Odlum-Blair - London Health Sciences Centre
J. Motiejunas - London Health Sciences Centre
S. McConnell - London Health Sciences Centre
A. Lucas - Western University
Contributors: I. V. Bigio (Editor)
G. J. Muller (Editor)
G. J. Puppels (Editor)
R. W. Steiner (Editor)
K. Swanberg (Editor)
Publication Details: Proceedings of SPIE - The International Society for Optical Engineering; Optical Biopsy and Tissue Optics, Vol.4161
Publisher: Affiliation: John P. Robarts Research Institute, University of Western Ontario, 100 Perth Drive, PO Box 5015, London, Ont. N6A 5K8, Canada; Correspondence Address: Lucas, A.; John P. Robarts Research Institute, 100 Perth Drive, PO Box 5015, London, Ont. N6A 5K8, Canada; email: arl@rri.on.ca
Identifiers: 0277786X; 991006029335002656
Academic Unit: Hospital Medicine
Language: English
Resource Type: Conference proceeding

A three tiered fluorescence-based system for monitoring activation-related changes in human platelets

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