Abstract
The problem of changes in the bone marrow of patients with extramedullary malignant neoplasms was inspired by the finding of bronchogenic carcinoma in an individual, who, during life, had a severe anemia and a marked leukemoid blood picture with eosinophilia. Diagnostic procedures and therapy were directed toward the clinical diagnosis of leukemia. A perusal of English and American literature at that time revealed only very general statements regarding bone marrow changes associated with malignancy. It was felt that a detailed study of the bone marrow was indicated to determine more specifically what changes, if any, may be found which would be of assistance in diagnosis, prognosis, and treatment of patients with malignancy.