Abstract
Connective tissue, the most common histologic unit in the human body, has been the subject of intense research for the past twenty years. A review of the literature indicates that a truly detailed accounting of the chemical components of this tissue is lacking. | Connective tissue, a mesodermally derived entity, consists of cells, fibers, and a ground substance, the function of which is to support and compartmentalize the various tissues and organs of the body. The type and the arrangements of the fibers, and the nature of the ground substance form the basis for the subdividing of adult connective tissue into three groups including cartilage, bone, and connective tissue proper. The varying functions of these anatomically and histologically diverse groups may well be a reflection of a relatively dissimilar chemical composition. This study will address itself to components of the ground substance. | The ground substance, or matrix, is an amorphous gel-like structure in which fibers and cells seem to be embedded. It is histologically homogeneous and in addition to architectural functions it provides a medium for nutrient and metabolite exchange. It participates in the homeostasis of the cellular environment and plays a role in the changes which develop during growth and differentiation, regeneration, and aging. Ground substance plays a prominent role in protecting the body from bacterial invasion and trauma, and is responsive to some hormones.