Abstract
Since the use of irradiation in the treatment of malignancy, it has been known that certain biological changes take place within the irradiated cells. The actual basis for biological changes within a living cell are still an unknown quantity, but when the most intricate or basic changes are understood, many baffling questions may be answered. Although these basic changes are not known to us or understood by us as yet, there are other changes in the cell which are visible to us cytologically and can be used to advantage in the light of our present knowledge. These cytological changes, until the present time, have been studied in the tissue section or biopsy during x-ray therapy.