Abstract
The object of this investigation was to prepare iodo derivatives of a substituted diphenyl ether, and its intermediate compounds, The diphenyl ether studied was 4-phenoxyhydrocinnamic acid. | The study of iodo derivatives of diphenyl ether has been recently stimulated by the work of Harington and Barger, who proved quite conclusively that thyroxine was a tetra iodo derivative of a substituted diphenyl ether. Thyroxine, a normal constituent of the thyroid gland has been the subject of much controversy in the last twenty years. The work of Harington and Barger, however, has settled the question as to the constitution of thyroxine, and much is now being done toward studying its physiological activity.