Abstract
In the past, a great number of Investigations have been conducted to study the various effects of carcinogenic agents on laboratory animals. Some of the earlier works were devoted to observing the effect of certain carcinogens In relation to those viruses which had the ability to produce tumorous growths in experimental animals. It has been shown that these animals, pretreated with certain carcinogens, which included 20-methylcholánthrene, exhibited marked alteration as to characteristics of these tumor-producing viruses. Other organisms have been reported stimulated in growth by its presence. This obviously suggests the possibility that the carcinogens might have imparted a conditioning effect to the cells rendering them more susceptible to these infectious agents. The primary purpose of this investigation is directed towards the observation and explanation of the effects, If any, this predisposition of such treated cells would have in terms of multiplication and growth of vaccinia virus.