13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

Ferenc Ötvös; Géza Tóth; Sándor Lovas; Csaba Simon; Sándor Hosztafi

doi:10.1002/hlca.19960790114

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13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

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13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

Ferenc Ötvös, Géza Tóth, Sándor Lovas, Csaba Simon and Sándor Hosztafi

Helvetica Chimica Acta, Vol.79(1), pp.133-136

1996

DOI: https://doi.org/10.1002/hlca.19960790114

Abstract

Catalysis

Biochemistry

Drug Discovery

Physical and Theoretical Chemistry

Organic Chemistry

Inorganic Chemistry

The synthesis of 6β-(methylfumaramido) and 6β-chloroacetamido derivatives 1b and 1c of 6β-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives 1e and 1f are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c, e, f).

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Title: 13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity
Creators: Ferenc Ötvös (Author) - Hungarian Academy of Sciences;Creighton University
Géza Tóth (Author) - Hungarian Academy of Sciences
Sándor Lovas (Author) - Department of Biomedical Sciences
Csaba Simon (Author) - Alkaloida Chemical Company Ltd.
Sándor Hosztafi (Author) - Alkaloida Chemical Company Ltd.
Additional links: Anon
Publication Details: Helvetica Chimica Acta, Vol.79(1), pp.133-136
Series: 79
Number of pages: 4
Identifiers: 991005930939402656
Academic Unit: Biomedical Sciences
Language: English
Resource Type: Journal article

13. Synthesis and tritium labelling of 6β-amino-4,5α-epoxyraorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with μ opioid agonist activity

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