A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1

S. L. Neuhausen; J. Swensen; Y. Miki; Q. Llu; S. Tavtiglan; D. Shattuck-eidens; A. Kamb; M. R. Hobbs; J. Gingrich; H. Shizuya; U. J. Kim; C. Cochran; P. A. Futreal; R. W. Wiseman; H. T. Lynch; P. Tonin; S. Narod; L. Cannon-albright; M. H. Skolnick; D. E. Goldgar

doi:10.1093/hmg/3.11.1919

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A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1

Journal article

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A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1

S. L. Neuhausen, J. Swensen, Y. Miki, Q. Llu, S. Tavtiglan, D. Shattuck-eidens, A. Kamb, M. R. Hobbs, J. Gingrich, H. Shizuya, …

Human Molecular Genetics, Vol.3(11), pp.1919-1926

11/1994

DOI: https://doi.org/10.1093/hmg/3.11.1919

PMID: 7874107

Abstract

Molecular Biology

Genetics

Genetics(clinical)

BRCA1, a breast and ovarian cancer susceptibility locus, has been isolated and maps to 17q21. A physical map of the BRCA1, region which extended from the proximal boundary at D17S776 to the distal boundary at D17S78 was constructed and consists of 51 sequence tagged sites (STSs) from P1 and YAC ends, nine new short-tandem repeat (STR) polymorphic markers, and eight identified genes. The contig, which spans the estimated 2.3 Mb region, contains 29 P1s, 11 YACs, two BACs, and one cosmid. Based on key recombinants in two linked families, BRCA1 was further localized to a region bounded by D17S1321 on the proximal side and D17S1325 on the distal side. Within this estimated 600 kb region, the contig was composed completely of P1s and BACs ordered by STS-content mapping and confirmed by DNA restriction fragment fingerprinting.

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Title: A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1
Creators: S. L. Neuhausen (Author) - Department of Medical Informatics
J. Swensen (Author) - Department of Medical Informatics
Y. Miki (Author) - Department of Medical Informatics
Q. Llu (Author) - Myriad Genetics Laboratories
S. Tavtiglan (Author) - Myriad Genetics Laboratories
D. Shattuck-eidens (Author) - Myriad Genetics Laboratories
A. Kamb (Author) - Myriad Genetics Laboratories
M. R. Hobbs (Author) - Department of Human Genetics
J. Gingrich (Author) - Lawrence Berkeley National Laboratory
H. Shizuya (Author) - California Institute of Technology
U. J. Kim (Author) - California Institute of Technology
C. Cochran (Author) - National Institutes of Health
P. A. Futreal (Author) - National Institutes of Health
R. W. Wiseman (Author) - National Institutes of Health
H. T. Lynch (Author) - Creighton University
P. Tonin (Author) - McGill University
S. Narod (Author) - McGill University
L. Cannon-albright (Author) - University of Utah
M. H. Skolnick (Author) - Myriad Genetics Laboratories
D. E. Goldgar (Author) - Department of Medical Informatics
Additional links: Dick, S.H.; Kurgan, L.; Musilek, P.; Pedrycz, W.; Reformat, M.
Publication Details: Human Molecular Genetics, Vol.3(11), pp.1919-1926
Series: 3
Number of pages: 8
Identifiers: 991005929542102656
Academic Unit: Creighton University
Language: English
Resource Type: Journal article

A P1-based physical map of the region from D17S776 to D17S78 containing the breast cancer susceptibility gene BRCA1

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