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A customized genetic approach to the number one killer: Coronary artery disease
Journal article

A customized genetic approach to the number one killer: Coronary artery disease

R. Roberts
Current opinion in cardiology, Vol.23(6)
2008
DOI: https://doi.org/10.1097/HCO.0b013e32830e6b4e

Abstract

9p21 variant Coronary artery disease Genetic susceptibility Risk variant Single nucleotide polymorphisms anticoagulant agent hydroxymethylglutaryl coenzyme A reductase inhibitor warfarin African American Asian Brugada syndrome cardiovascular disease Caucasian chromosome 9p chromosome 9p21 clinical trial coronary risk DNA microarray drug cost ethnic difference ethnic group gene frequency gene identification genetic analysis genetic association genetic identification genetic predisposition genetic risk genetic screening genetic variability genotype heart arrhythmia heart ventricle arrhythmia heredity heterozygosity heterozygote high throughput screening homozygosity homozygote human human genome project hypertrophic cardiomyopathy long QT syndrome low drug dose note pharmacogenetics priority journal risk factor sample size single nucleotide polymorphism sudden death Chromosomes, Human, Pair 9 Death, Sudden, Cardiac Evidence-Based Medicine Genetic Predisposition to Disease Humans Polymorphism, Single Nucleotide Risk Assessment Risk Factors
Thus, identification of predisposition to CAD is well underway with genome-wide association studies and the first common genetic risk variant, 9p21, has been identified. © 2008 Wolters Kluwer Health|Lippincott Williams & Wilkins.

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