A large multisite cancer family is linked to BRCA2

P. Tonin; P. Ghadirian; C. Phelan; G. M. Lenoir; H. T. Lynch; F. Letendre; D. Belanger; M. Monté; S. A. Narod

doi:10.1136/jmg.32.12.982

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A large multisite cancer family is linked to BRCA2

Journal article

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Peer reviewed

A large multisite cancer family is linked to BRCA2

P. Tonin, P. Ghadirian, C. Phelan, G. M. Lenoir, H. T. Lynch, F. Letendre, D. Belanger, M. Monté and S. A. Narod

Journal of Medical Genetics, Vol.32(12), pp.982-984

1995

DOI: https://doi.org/10.1136/jmg.32.12.982

PMCID: PMC1051783

PMID: 8825930

Abstract

Genetics

Genetics(clinical)

We identified a large French-Canadian family with 21 cases of breast cancer, including two affected brothers. Segregation of markers from chromosome 13q in this family showed linkage to the BRCA2 gene locus (lod=3.67 at D13S289). A number of cancers of other types occurred in this family, including three cases of prostate cancer and two cases of lymphoma. The penetrance of breast cancer among BRCA2 carriers is estimated to be 75% to the age of 70.

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Title: A large multisite cancer family is linked to BRCA2
Creators: P. Tonin (Author) - McGill University
P. Ghadirian (Author) - University of Montreal
C. Phelan (Author) - McGill University;Karolinska Institutet
G. M. Lenoir (Author) - International Agency for Research on Cancer
H. T. Lynch (Author) - Creighton University
F. Letendre (Author) - University of Montreal
D. Belanger (Author) - University of Montreal
M. Monté (Author) - University of Montreal
S. A. Narod (Author) - McGill University
Publication Details: Journal of Medical Genetics, Vol.32(12), pp.982-984
Series: 32
Number of pages: 3
Identifiers: 991005930337902656
Academic Unit: Creighton University
Language: English
Resource Type: Journal article