A standard numbering scheme for class C β-lactamases

Andrew R. Mack; Melissa D. Barnes; Magdalena A. Taracila; Andrea M. Hujer; Kristine M. Hujer; Gabriel Cabot; Michael Feldgarden; Daniel H. Haft; William Klimke; Focco Van Den Akker; Alejandro J. Vila; Andrea Smania; Shozeb Haider; Krisztina M. Papp-Wallace; Patricia A. Bradford; Gian Maria Rossolini; Jean Denis Docquier; Jean Marie Frère; Moreno Galleni; Nancy D. Hanson; Antonio Oliver; Patrick Plésiat; Laurent Poirel; Patrice Nordmann; Timothy G. Palzkill; George A. Jacoby; Karen Bush; Robert A. Bonomo

doi:10.1128/AAC.01841-19

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A standard numbering scheme for class C β-lactamases

Journal article

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A standard numbering scheme for class C β-lactamases

Andrew R. Mack, Melissa D. Barnes, Magdalena A. Taracila, Andrea M. Hujer, Kristine M. Hujer, Gabriel Cabot, Michael Feldgarden, Daniel H. Haft, William Klimke, Focco Van Den Akker, …

Antimicrobial agents and chemotherapy, Vol.64(3), e01841-19

2020

DOI: https://doi.org/10.1128/AAC.01841-19

PMID: 31712217

Abstract

Pharmacology

Pharmacology (medical)

Infectious Diseases

Unlike for classes A and B, a standardized amino acid numbering scheme has not been proposed for the class C (AmpC) β-lactamases, which complicates communication in the field. Here, we propose a scheme developed through a collaborative approach that considers both sequence and structure, preserves traditional numbering of catalytically important residues (Ser64, Lys67, Tyr150, and Lys315), is adaptable to new variants or enzymes yet to be discovered and includes a variation for genetic and epidemiological applications.

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Title: A standard numbering scheme for class C β-lactamases
Creators: Andrew R. Mack (Author) - Case Western Reserve University;Department of Veterans Affairs
Melissa D. Barnes (Author) - Case Western Reserve University;Department of Veterans Affairs
Magdalena A. Taracila (Author) - Case Western Reserve University;Department of Veterans Affairs
Andrea M. Hujer (Author) - Case Western Reserve University;Department of Veterans Affairs
Kristine M. Hujer (Author) - Case Western Reserve University;Department of Veterans Affairs
Gabriel Cabot (Author) - Instituto de Salud Carlos III;Hospital Son Dureta
Michael Feldgarden (Author) - National Institutes of Health
Daniel H. Haft (Author) - National Institutes of Health
William Klimke (Author) - National Institutes of Health
Focco Van Den Akker (Author) - Case Western Reserve University
Alejandro J. Vila (Author) - Department of Veterans Affairs;Consejo Nacional de Investigaciones Científicas y Técnicas;Plataforma Argentina de Biología Estructural y Metabolómica PLABEM;Universidad Nacional de Rosario
Andrea Smania (Author) - Universidad Nacional de Cordoba
Shozeb Haider (Author) - University College London
Krisztina M. Papp-Wallace (Author) - Case Western Reserve University;Department of Veterans Affairs
Patricia A. Bradford (Author) - Antimicrobial Development Specialists, LLC
Gian Maria Rossolini (Author) - University of Florence;Azienda Ospedaliera Careggi
Jean Denis Docquier (Author) - University of Siena
Jean Marie Frère (Author) - University of Liege
Moreno Galleni (Author) - University of Liege
Nancy D. Hanson (Author) - Department of Medical Microbiology and Immunology
Antonio Oliver (Author) - Instituto de Salud Carlos III;Hospital Son Dureta
Patrick Plésiat (Author) - Université de Franche-Comté;Université de Bourgogne Franche-Comté;Centre national de référence de la résistance aux antibiotiques
Laurent Poirel (Author) - Faculty of Science and Medicine;University of Fribourg
Patrice Nordmann (Author) - Faculty of Science and Medicine;University of Fribourg
Timothy G. Palzkill (Author) - Baylor College of Medicine
George A. Jacoby (Author) - Lahey Hospital & Medical Center
Karen Bush (Author) - Indiana University Bloomington
Robert A. Bonomo (Author) - Case Western Reserve University;Department of Veterans Affairs
Additional links: Cameron, John L.
Publication Details: Antimicrobial agents and chemotherapy, Vol.64(3), e01841-19
Series: 64
Grant note: Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to R.A.B. under award numbers R01AI100560, R01AI063517, and R01AI072219. This study was also supported in part by funds and/or facilities provided by the Cleveland Department of Veterans Affairs to K.M.P.-W. and R.A.B., Veterans Affairs Merit Review Program award number 1I01BX002872 to K.M.P.-W., Veterans Affairs Merit Review Program award number 1I01BX001974 to R.A.B. from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development, and by the Geriatric Research Education and Clinical Center VISN 10. The work of Michael Feldgarden, Daniel H. Haft, and William Klimke was supported by the Intramural Research Program of the National Library of Medicine, National Institutes of Health.
Identifiers: 991005930359702656
Academic Unit: Med. Microbiology & Immunology
Language: English
Resource Type: Journal article

A standard numbering scheme for class C β-lactamases

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