Abciximab and bleeding during coronary surgery: Results from the EPILOG and EPISTENT trials

A. Michael Lincoff; Leroy A. Lenarz; George J. Despotis; Peter K. Smith; Joan E. Booth; Russell E. Raymond; Shelly K. Sapp; Catherine F. Cabot; James E. Tcheng; Robert M. Califf; Mark B. Effron; Eric J. Topol; Dean J. Kereiakes; John Paul Runyon; Thomas Kelly; George Timmis; Neal S. Kleiman; Jeffrey Kramer; David Talley; Frank I. Navetta; Phillip Kraft; James Ferguson; Kevin Browne; James Blankenship; Russell Ivanhoe; Neal Shadoff; Mark Taylor; Gerald Gacioch; Eric Bates; H. A. Snyder; Theodore A. Bass; Philip Bear; Larry Hattel; H. Vernon Anderson; Bruce Hettleman; Paul S. Teirstein; Ian Sarembock; Charles J. Davidson; Frank V. Aguirre; Michael Azrin; Seth Worley; Jean Francois Marquis; Douglas J. Spriggs; Mark W. Weston; Barry S. George; Donald R. Ricci; Carl W. Hartman; Anthony Farah; Gary Sander; Bernard M. Reen; Richard Heuser; Timothy Larkin; Jeffrey Popma; Mark L. Sanz; Jeffrey Burton; Robert I.G. Brown; William J. French; Allan G. Adelman; Ronald Gottlieb; Spencer B. King; John Ducas; Judith S. Hochman; Blair J. O'Neill; Po Kee Cheung; Merril Knudtson; Joseph Samaha; Lloyd W. Klein; David Almond; Michael J. Rosenberg; Michael Unks; Eric Cohen; John C. Webb; Jean Francois Tanguay; Patrick S. Coleman; Mark Thompson; Alan Gradman; Steven Yakubov; Mark Tannenbaum; Mark Gonzalez; Richard Bach; Frank E. Cummins; Charles Lucore; Brent Muhlestein; Robert Chisholm; Michael Del Core

doi:10.1016/S0003-4975(00)01343-6

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Abciximab and bleeding during coronary surgery: Results from the EPILOG and EPISTENT trials

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Abciximab and bleeding during coronary surgery: Results from the EPILOG and EPISTENT trials

A. Michael Lincoff, Leroy A. Lenarz, George J. Despotis, Peter K. Smith, Joan E. Booth, Russell E. Raymond, Shelly K. Sapp, Catherine F. Cabot, James E. Tcheng, Robert M. Califf, …

Annals of Thoracic Surgery, Vol.70(2), pp.516-526

2000

DOI: https://doi.org/10.1016/S0003-4975(00)01343-6

PMID: 10969673

Abstract

Surgery

Pulmonary and Respiratory Medicine

Cardiology and Cardiovascular Medicine

Background. Abciximab during percutaneous coronary revascularization reduces ischemic complications, but concern exists regarding increased bleeding risk should emergency coronary surgical procedures be required. Methods. Outcomes were assessed among 85 patients who required coronary artery bypass grafting operations after coronary intervention in two randomized placebo-controlled trials of abciximab. Comparisons were made between patients in the pooled placebo and abciximab groups. Results. The incidence of coronary surgical procedures was 2.17% and 1.28% among patients randomized to placebo and abciximab, respectively (p = 0.021). Platelet transfusions were administered to 32% and 52% of patients in the placebo and abciximab groups, respectively (p = 0.059). Rates of major blood loss were 79% and 88% in the placebo and abciximab groups, respectively (p = 0.27); transfusions of packed red blood cells or whole blood were administered in 74% and 80% of patients, respectively (p = 0.53). Surgical reexploration for bleeding was required in 3% and 12% of patients, respectively. Death and myocardial infarction tended to occur less frequently among patients who had received abciximab. Conclusions. Urgent coronary artery bypass grafting operations can be performed without an incremental increase in major hemorrhagic risk among patients on abciximab therapy. (C) 2000 by The Society of Thoracic Surgeons.

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Title: Abciximab and bleeding during coronary surgery
Creators: A. Michael Lincoff (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Leroy A. Lenarz (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
George J. Despotis (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Peter K. Smith (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Joan E. Booth (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Russell E. Raymond (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Shelly K. Sapp (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Catherine F. Cabot (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
James E. Tcheng (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Robert M. Califf (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Mark B. Effron (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Eric J. Topol (Author) - Cleveland Clinic Foundation;Eli Lilly;Washington University St. Louis;Duke University;Centocor, Inc.
Dean J. Kereiakes (Author) - University of Cincinnati
John Paul Runyon (Author) - University of Cincinnati;Health Alliance
Thomas Kelly (Author) - Cone Health
George Timmis (Author) - William Beaumont Hospital
Neal S. Kleiman (Author) - Baylor University Medical Center at Dallas;Baylor College of Medicine
Jeffrey Kramer (Author) - Our Lady of Lourdes Medical School;Our Lady of Lourdes Medical Center
David Talley (Author) - University Hospital of Arkansas
Frank I. Navetta (Author) - Mother Frances Hospital
Phillip Kraft (Author) - Henry Ford Health System
James Ferguson (Author) - Texas Heart Institute
Kevin Browne (Author) - Lakeland Regional Medical Center;Watson Clinic
James Blankenship (Author) - Geisinger Medical Center
Russell Ivanhoe (Author) - AdventHealth Orlando
Neal Shadoff (Author) - Presbyterian Healthcare Services, New Mexico
Mark Taylor (Author) - Deborah Heart and Lung Center
Gerald Gacioch (Author) - Rochester General Hospital
Eric Bates (Author) - University of Michigan, Ann Arbor
H. A. Snyder (Author) - Cooper University Hospital
Theodore A. Bass (Author) - University of Florida
Philip Bear (Author) - Methodist Hospital-Iowa Heart
Larry Hattel (Author) - Cheyenne Regional Medical Center
H. Vernon Anderson (Author) - Hermann Hospital;Division of Trauma Services
Bruce Hettleman (Author) - Dartmouth College
Paul S. Teirstein (Author) - Scripps Research Institute
Ian Sarembock (Author) - University of Virginia
Charles J. Davidson (Author) - Northwestern University
Frank V. Aguirre (Author) - Saint Louis University
Michael Azrin (Author) - University of Connecticut;Institute of Living
Seth Worley (Author) - Lancaster General Hospital;St. Joseph Hospital;Lancaster Heart Foundation
Jean Francois Marquis (Author) - Ottawa Hospital Research Institute
Douglas J. Spriggs (Author) - Morton Plant Mease Health Care
Mark W. Weston (Author) - University of South Florida
Barry S. George (Author) - Riverside Methodist Hospital
Donald R. Ricci (Author) - University of British Columbia;Vancouver Hospital-Health Science Centre
Carl W. Hartman (Author) - Sentara Norfolk General Hospital
Anthony Farah (Author) - Allegheny General Hospital
Gary Sander (Author) - University Medical Center New Orleans
Bernard M. Reen (Author) - Presbyterian Healthcare, North Carolina
Richard Heuser (Author) - Arizona Heart Institute
Timothy Larkin (Author) - Evanston Northwestern Healthcare
Jeffrey Popma (Author) - Washington Hospital Center
Mark L. Sanz (Author) - St. Patrick Hospital and Health Sciences Center;Western Montana Clinic
Jeffrey Burton (Author) - University of Alberta
Robert I.G. Brown (Author) - University of British Columbia
William J. French (Author) - University of California at Los Angeles
Allan G. Adelman (Author) - University of Toronto;Toronto Hospital
Ronald Gottlieb (Author) - Graduate Hospital
Spencer B. King (Author) - Emory University
John Ducas (Author) - University of Manitoba
Judith S. Hochman (Author) - St. Luke's-Roosevelt Hospital Center
Blair J. O'Neill (Author) - QEII Health Sciences Centre
Po Kee Cheung (Author) - University of Manitoba
Merril Knudtson (Author) - Foothills Medical Centre
Joseph Samaha (Author) - Baptist Memorial Health Care Corporation
Lloyd W. Klein (Author) - Rush University
David Almond (Author) - Western University
Michael J. Rosenberg (Author) - Advocate Health Care
Michael Unks (Author) - United States Air Force Academy
Eric Cohen (Author) - University of Toronto
John C. Webb (Author) - St. Paul's Hospital, Vancouver
Jean Francois Tanguay (Author) - University of Montreal
Patrick S. Coleman (Author) - Northern Californian Medical Association
Mark Thompson (Author) - Rochester General Hospital
Alan Gradman (Author) - Western Pennsylvania Hospital
Steven Yakubov (Author) - MidWest Cardiology Research Foundation
Mark Tannenbaum (Author) - Iowa Heart Center
Mark Gonzalez (Author) - Orlando Regional Medical Center
Richard Bach (Author) - Saint Louis University
Frank E. Cummins (Author) - Milwaukee Heart and Vascular Clinic
Charles Lucore (Author) - Prairie Cardiovascular Consultants, Ltd.
Brent Muhlestein (Author) - Latter Day Saints Hospital
Robert Chisholm (Author) - University of Toronto
Michael Del Core (Author) - Department of Medicine
Additional links: Clark, Terry D.; Potter, Joshua D.; Larson, Jennifer M.; Mordeson, John N.; Wierman, Mark J.
Publication Details: Annals of Thoracic Surgery, Vol.70(2), pp.516-526
Series: 70
Number of pages: 11
Identifiers: 991005930462002656
Academic Unit: General Medicine
Language: English
Resource Type: Journal article

Abciximab and bleeding during coronary surgery: Results from the EPILOG and EPISTENT trials

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