Abstract
Abstract Purpose: Ceruminous adenocarcinoma (CA) is an uncommon malignancy that arises from the ceruminous glands located in the external auditory canal. Although rare, 25% of patients with CA die of the disease within 2 years of presentation. CA has a 10-year survival rate of 60% with radiation treatment and 30% without radiation treatment. The rarity of this tumor type, combined with a lack of published data, makes it difficult to fully understand its clinical characteristics and optimal management strategies. A study on its epidemiology could offer valuable insight into the diagnostic trend of the disease. The Surveillance Epidemiology and End Results (SEER) database was analyzed to determine the demographic factors in patients diagnosed with CA. Methods: A retrospective cohort analysis utilizing the SEER database from 2000 to 2019 included patients with a confirmed diagnosis of CA (N=45). Cross-tabulation of the demographic factors (age, sex, race, marital status, and Hispanic origin) was analyzed by Pearson’s chi-squared test (p=0.05) and incidence trends were interpreted in regression analysis. Results: There has been a downward trend in incidence rates of patients diagnosed with CA since 2007 (R2=0.139) with an average of 2.25 diagnoses per year. A total of 45 patients were identified in the database with a confirmed diagnosis of CA. The average age of diagnosis was 60.0 years (SD=15.4, range=26–88 years). The top primary site was the external ear (69%), followed by skin of the trunk (8.9%) and skin of the lower limb (6.7%). The majority of the patients were male (53%), non-Spanish-Hispanic-Latino (91%), and White (82%) followed by Black (8.9%), and Asian/Pacific Islanders (6.7%). More patients (40%) were married at the time of diagnosis than those who were widowed (13%), single (9%), or divorced (7%), with the rest having unknown marital status (31%). There were no statistically significant differences between the demographic factors and the primary site at which CA presents. Conclusion: The majority of CA patients tend to be non-Hispanic White males with a declining number of cases each year. Further research is needed to better understand the impact of demographic factors on the diagnosis and overall survival of patients with CA, as well as the reason for the decreased incidence and possible underdiagnosis of the disease. Citation Format: Beau Hsia, Darby Keirns, Peter Silberstein, Xinxin Wu. A SEER Analysis of Demographic Factors Associated With Ceruminous Adenocarcinoma, 2000-2019 [abstract]. In: Proceedings of the 11th Annual Symposium on Global Cancer Research; Closing the Research-to-Implementation Gap; 2023 Apr 4-6. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(6_Suppl):Abstract nr 4.