Abstract
Abstract Purpose: Skin appendage carcinoma (SAC) is a malignant neoplasm arising from hair follicles or sweat glands. The incidence rates of cutaneous-type appendageal carcinomas have been increasing in the United States. The epidemiology of SAC is poorly understood due to its rarity. The National Cancer Database (NCDB) was analyzed to determine the primary sites at which SAC presents and the prognostic factors relating to overall survival. Methods: A retrospective cohort analysis utilizing the NCDB from 2004 to 2019 included patients diagnosed with histologically confirmed SAC between 0-99 years (N=815). Demographic factors were analyzed using Pearson Chi-squared tests, and a multivariate analysis of factors in overall survival was performed via Cox Regression. Results: The number of cases diagnosed with SAC has steadily increased from 2004 to 2019 (43 and 67, respectively). The majority of the cases analyzed were White (89.8%), male (57.5%), non-Hispanic (91.0%), located in the Atlantic regions (39.9%), insured by Medicare (55.1%), and had a median household income in the top quartile (44.9%). The mean age at diagnosis was 69.1 years (std. deviation=13.1) with an average comorbidity Charlson-Deyo Score of 0.3 (std. deviation=0.7). The most common primary site for SAC was the skin of the face (23.9%), followed by the scalp and neck (22.2%), the trunk (18.7%), and the upper limb and shoulder (14.2%). Site-specific surgical procedure of the primary site was performed in 94.6% of cases. Prognostic factors leading to better overall survival include age at diagnosis younger than 65 years of age (p<0.001; 95% CI= [1.5-3.2]), lower Charlson-Deyo scores (p<0.001), private insurance status (p<0.001; 95% CI= [0.2-0.9]), and surgery of the primary site (p<0.001; 95% CI= [<0.1-5.7]). Conclusions: There has been an upward trend in the diagnosis of SAC since 2004, with a predilection for White, non-Hispanic, older men in the South and Middle Atlantic regions. Given the rarity of the disease, this study serves as a valuable tool for understanding the prognostic trend of SAC. Citation Format: Xinxin Wu, Michelle Swedek, Peter Silberstein, Victoria Vardell. Prognostic Factors in the Overall Survival of Skin Appendage Carcinoma: An NCDB Analysis [abstract]. In: Proceedings of the 11th Annual Symposium on Global Cancer Research; Closing the Research-to-Implementation Gap; 2023 Apr 4-6. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2023;32(6_Suppl):Abstract nr 70.