Abstract
Context. - Renin profiling and age-race subgroup may help select single- drug therapy for stage 1 and stage 2 hypertension. Objective. - To compare the plasma renin profiling and age-race subgroup methods as predictors of response to single-drug therapy in men with stage 1 and 2 hypertension as defined by the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Design. - The Veterans Affairs Cooperative on Single-Drug Therapy of Hypertension, a randomized controlled trial. Setting. - Fifteen Veterans Affairs hypertension centers. Patients. - A total of 1105 ambulatory men with entry diastolic blood pressure (DBP) of 95 to 109 mm Hg, of whom 1031 had valid plasma and urine samples for renin profiling. Interventions. - Randomization to 1 of 6 antihypertensive drugs: hydrochlorothiazide, atenolol, captopril, clonidine, diltiazem (sustained release), or prazosin. Main Outcome Measure. - Treatment response as assessed by percentage achieving goal DBP (