Abstract
e17097 Background: Mixed acinar ductal carcinoma (MADC) is a rare form of prostate carcinoma with both acinar carcinoma and ductal adenocarcinoma components, originating in the prostate. Despite their infrequent occurrence, mixed carcinomas have demonstrated increasing prevalence in recent years and are associated with poor prognosis. This is especially concerning since prostate malignancies are one of the most common in men across the world. Thus, understanding the demographic patterns related to this malignancy can offer insight into its epidemiology, diagnosis, and relevant risk factors. The National Cancer Database (NCDB) was used to analyze these patterns in mixed acinar ductal carcinoma. Methods: A retrospective cohort analysis using data from the NCDB was performed for patients diagnosed with mixed acinar ductal carcinoma, ICD-O-3 Code 8552, between 2018 and 2020 (N = 206). Demographic factors were analyzed using descriptive statistics, including age, sex, race, Hispanic heritage, type of facility, distance from facility, and Charles/Deyo score. Statistical regression analysis was used to evaluate incidence patterns. Results: Between 2018 and 2020, 206 patients with a MADC diagnosis were identified with a gradually increasing incidence of diagnosis (R² = 0.2276). Of this cohort, an overwhelming majority identified as male (98.5%) and of White (83%) and non-Hispanic (95.6%) origin. The majority of patients (54.4%) received coverage from Medicare and another 39.5% were under private insurance/managed care. The most common primary site was the prostate (95.1%). NCDB Analytic Staging was not applicable in most cases (82%) and most individuals had a total Charlson-Deyo comorbidity score of 0 (77.2%). The average age at diagnosis was 67.2 years (SD = 8.6, range = 43 – 90 years). Most patients (84.0%) received surgery; following resection of the primary tumor, over half of these patients (53.4%) had no residual tumor. Many of the patients (97.4%) survived at least thirty days after primary surgery, with a similar survival rate (94.9%) after ninety days. The estimated two-year survival rate was 93.9% and the mean survival after diagnosis was 43.2 months (3.6 years). Conclusions: Based on our literature searches, this is the first analysis using NCDB data for mixed acinar ductal carcinoma addressing the lack of understanding of the demographic aspects of the disease. MADC patients were mostly White and non-Hispanic males. Most of these patients held Medicare as a primary insurance, likely due to the overall older population impacted by this cancer. MADC primarily affected the prostate and the patients typically had a favorable prognosis following surgery of the primary site. Additional investigations are necessary to determine the effects of these socioeconomic and demographic factors on individuals with mixed acinar ductal carcinoma.