Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells

Dannah R. Miller; Matthew A. Ingersoll; Yu-wei Chou; C. Brent Wakefield; Yaping Tu; Fen-Fen Lin; William G. Chaney; Ming-Fong Lin

Journal article

Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells

Dannah R. Miller, Matthew A. Ingersoll, Yu-wei Chou, C. Brent Wakefield, Yaping Tu, Fen-Fen Lin, William G. Chaney and Ming-Fong Lin

Journal of oncology research and therapy, Vol.3(5)

01/01/2017

PMCID: PMC6641547

PMID: 31328181

Abstract

Anti-Androgens

Castration-Resistant Prostate Cancer

Combination Treatments

Prostate Cancer

Statins

The treatment of castration-resistant (CR) prostate cancer (PCa) is limited. A sub-population of CR PCa tumors can synthesize androgens for intracrine androgen receptor (AR) activation, thus targeting androgen biosynthesis could be an effective therapeutic option for these patients. We determined that androgen biosynthesis inhibitors simvastatin, atorvastatin, and ketoconazole directly inhibit growth, migration, and colony formation of LNCaP C-81 cells, which exhibit de novo androgen biosynthesis, with simvastatin being the most effective. Importantly, in combination treatments, statins specifically enhanced growth suppression with added effects by anti-androgen abiraterone acetate on the CR PCa cells. Thus, statins can be used in conjunction with abiraterone acetate to enhance anti-androgen therapy for CR PCa.

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Title: Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells
Creators: Dannah R. Miller - Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, USA Human Genetic Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, China
Matthew A. Ingersoll - Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, USA Human Genetic Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, China
Yu-wei Chou - Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, USA Human Genetic Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, China
C. Brent Wakefield - Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, USA Human Genetic Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, China
Yaping Tu - Creighton University
Fen-Fen Lin - Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, USA Human Genetic Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, China
William G. Chaney - Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, USA Human Genetic Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, China
Ming-Fong Lin - Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA BioBank/Tissue Bank, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, China Section of Urological Surgery, School of Medicine, University of Nebraska Medical Center, Omaha, NE, USA Department of Pharmacology, Creighton University School of Medicine, Omaha, NE, USA Human Genetic Laboratory, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE, USA Eppley Institute for Cancer Research, University of Nebraska, Medical Center, Omaha, NE, USA College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, China
Publication Details: Journal of oncology research and therapy, Vol.3(5)
Identifiers: 991005969883902656
Academic Unit: Pharmacology and Neuroscience
Language: English
Resource Type: Journal article

Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells

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