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Aplastic anaemia in pregnancy with severe thrombocytopenia refractory to platelet transfusion: a case and management plan
Journal article   Peer reviewed

Aplastic anaemia in pregnancy with severe thrombocytopenia refractory to platelet transfusion: a case and management plan

Adi Smolinsky, Michael P. Carson, Edwin R. Guzman, Angela Ranzini, Joanne Toscano and Amar Bukhari
Obstetric medicine, Vol.2(1), pp.26-29
03/01/2009
PMID: 27582802

Abstract

Life Sciences & Biomedicine Obstetrics & Gynecology Science & Technology
Aplastic anaemia is a rare haematological disorder during pregnancy, which when complicated by severe thrombocytopenia poses a significant maternal risk. A woman with aplastic anaemia and a platelet ( PLT) count of 11 X 10(9)/L refractory to PLT transfusion required caesarean delivery. Proactive planning by a multidisciplinary team, large volume PLT transfusion prior to surgery and postoperative uterine artery embolization resulted in avoidance of mortality. Maternal preferences should be discussed in detail due to the high risk of maternal morbidity and mortality associated with severe aplastic anaemia. This report outlines a management plan to address the medical and ethical issues faced when caring for a pregnant patient with severe aplastic anaemia and severe thrombocytopenia. We credit the good outcome to our proactive multidisciplinary approach.

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