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Busulfan-based reduced toxicity conditioning regimen used in hematopoietic stem cell transplantation in HLH patients results in sustained donor chimerism
Journal article   Peer reviewed

Busulfan-based reduced toxicity conditioning regimen used in hematopoietic stem cell transplantation in HLH patients results in sustained donor chimerism

E. Goode, H. Miller, D. Salzberg, C. Campbell, K. Beebe, C. Schwalbach, R.H. Adams and A. Ngwube
Pediatric Hematology and Oncology, Vol.38(4)
2021
DOI: https://doi.org/10.1080/08880018.2020.1868638

Abstract

alemtuzumab busulfan cyclophosphamide fludarabine methotrexate mycophenolate mofetil steroid tacrolimus thiotepa busulfan, adult allogeneic hematopoietic stem cell transplantation area under the curve CD4+ T lymphocyte CD8+ T lymphocyte child chimera DNA sequencing donor drug monitoring female gene mutation graft failure graft recipient graft versus host reaction haploidentical transplantation hemophagocytic syndrome human inappropriate vasopressin secretion Letter liver venoocclusive disease low drug dose male matched unrelated donor preschool child prophylaxis retrospective study risk factor school child short tandem repeat thrombotic thrombocytopenic purpura transplantation conditioning unrelated donor young adult hematopoietic stem cell transplantation transplantation conditioning, Busulfan Chimerism Hematopoietic Stem Cell Transplantation Humans Transplantation Conditioning

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