COVID-19 Positive Status is Associated with Increased In-hospital Mortality in Patients with Acute Myocardial Infarction: A Systematic Review and Meta-analysis

Nischit Baral; Waiel Abusnina; Shravya Balmuri; Amith Seri; Soumya Kambalapalli; Prem R. Parajuli; Basel Abdelazeem; Krishna P. Bashyal; Niranjan Ojha; Bidhya Timilsina; Timir K. Paul

doi:10.55729/2000-9666.1103

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COVID-19 Positive Status is Associated with Increased In-hospital Mortality in Patients with Acute Myocardial Infarction: A Systematic Review and Meta-analysis

Journal article

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COVID-19 Positive Status is Associated with Increased In-hospital Mortality in Patients with Acute Myocardial Infarction: A Systematic Review and Meta-analysis

Nischit Baral, Waiel Abusnina, Shravya Balmuri, Amith Seri, Soumya Kambalapalli, Prem R. Parajuli, Basel Abdelazeem, Krishna P. Bashyal, Niranjan Ojha, Bidhya Timilsina, …

Journal of community hospital internal medicine perspectives, Vol.12(4), pp.17-24

09/09/2022

DOI: https://doi.org/10.55729/2000-9666.1103

Abstract

Acute myocardial infarction

COVID-19

In-hospital mortality

Meta-analysis

Review

Systematic review

Patients hospitalized for acute myocardial infarction (AMI) may have concomitant positive coronavirus disease 2019 (COVID-19). We aimed to compare the risk of in-hospital mortality in patients primarily hospitalized for AMI with or without concomitant COVID-19 positive status. Using the random-effects model, we conducted a systematic review and meta-analysis of published articles from December 1, 2019, to April 1, 2022. There were eight studies with 10,128 patients, including 612 patients with COVID and 9516 patients without COVID. A total of 261 patients (42.64%) with COVID-19 positive and 612 patients (6.43%) with negative COVID-19 status died in the hospital. Pooled data showed that patients with a primary diagnosis of AMI with COVID-19 infection had more than five times increased risk of in-hospital mortality compared to patients without COVID-19 (OR: 5.06, 95% CI: 3.61, 7.09; I 2 = 35%, P < 0.001). However, pooled data from five studies with adjustment of baseline differences in patient demographics and characteristics, comorbidities, and in-hospital pharmacology revealed more than three times increased risk of in-hospital mortality compared to patients who had primary AMI without COVID-19 infection (aOR: 3.47, 95% CI: 2.21, 5.45; I 2 = 0%, P < 0.001). In subgroup analysis, ST-elevation myocardial infarction (STEMI) had lower in-hospital mortality (OR 4.23, 95% CI: 3.31, 5.40; I 2 = 0%, P < 0.001) compared to non-ST-segment elevation myocardial infarction (NSTEMI) (OR 9.97, 95% CI: 5.71, 17.41; I 2 = 0%, P < 0.001) (p-value = 0.006). Our study shows that COVID-19 infection is associated with increased in-hospital mortality in patients with index hospitalization for AMI.

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Title: COVID-19 Positive Status is Associated with Increased In-hospital Mortality in Patients with Acute Myocardial Infarction: A Systematic Review and Meta-analysis
Creators: Nischit Baral - Creighton University
Waiel Abusnina - Creighton University
Shravya Balmuri - Department of Medicine, McLaren Flint/Michigan State University, Flint, MI, Department of Internal Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, Department of Internal Medicine, Tower Health-Reading Hospital, Reading, PA, Department of Internal Medicine, Division of Cardiology, SUNY Upstate Medical University, Syracuse, NY, Department of Internal Medicine, Division of Cardiology, Howard University, Washington, DC, Department of Cardiovascular Sciences, University of Tennessee College of Medicine, Nashville, TN
Amith Seri - Creighton University
Soumya Kambalapalli - Department of Medicine, McLaren Flint/Michigan State University, Flint, MI, Department of Internal Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, Department of Internal Medicine, Tower Health-Reading Hospital, Reading, PA, Department of Internal Medicine, Division of Cardiology, SUNY Upstate Medical University, Syracuse, NY, Department of Internal Medicine, Division of Cardiology, Howard University, Washington, DC, Department of Cardiovascular Sciences, University of Tennessee College of Medicine, Nashville, TN
Prem R. Parajuli - Department of Medicine, McLaren Flint/Michigan State University, Flint, MI, Department of Internal Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, Department of Internal Medicine, Tower Health-Reading Hospital, Reading, PA, Department of Internal Medicine, Division of Cardiology, SUNY Upstate Medical University, Syracuse, NY, Department of Internal Medicine, Division of Cardiology, Howard University, Washington, DC, Department of Cardiovascular Sciences, University of Tennessee College of Medicine, Nashville, TN
Basel Abdelazeem - Creighton University
Krishna P. Bashyal - Department of Medicine, McLaren Flint/Michigan State University, Flint, MI, Department of Internal Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, Department of Internal Medicine, Tower Health-Reading Hospital, Reading, PA, Department of Internal Medicine, Division of Cardiology, SUNY Upstate Medical University, Syracuse, NY, Department of Internal Medicine, Division of Cardiology, Howard University, Washington, DC, Department of Cardiovascular Sciences, University of Tennessee College of Medicine, Nashville, TN
Niranjan Ojha - Department of Medicine, McLaren Flint/Michigan State University, Flint, MI, Department of Internal Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, Department of Internal Medicine, Tower Health-Reading Hospital, Reading, PA, Department of Internal Medicine, Division of Cardiology, SUNY Upstate Medical University, Syracuse, NY, Department of Internal Medicine, Division of Cardiology, Howard University, Washington, DC, Department of Cardiovascular Sciences, University of Tennessee College of Medicine, Nashville, TN
Bidhya Timilsina - Department of Medicine, McLaren Flint/Michigan State University, Flint, MI, Department of Internal Medicine, Division of Cardiology, Creighton University School of Medicine, Omaha, NE, Department of Internal Medicine, Tower Health-Reading Hospital, Reading, PA, Department of Internal Medicine, Division of Cardiology, SUNY Upstate Medical University, Syracuse, NY, Department of Internal Medicine, Division of Cardiology, Howard University, Washington, DC, Department of Cardiovascular Sciences, University of Tennessee College of Medicine, Nashville, TN
Timir K. Paul - Creighton University
Publication Details: Journal of community hospital internal medicine perspectives, Vol.12(4), pp.17-24
Publisher: Greater Baltimore Medical Center
Identifiers: 991005956260602656
Academic Unit: Cardiology
Language: English
Resource Type: Journal article