Abstract
A clinical pathologic study of 159 patients with endometrial cancer from a community hospital during 1971 to 1977 revealed that those women who developed cancer following long-term use of exogenous estrogens had more localized and better differentiated tumors than patients who had not used estrogens. However, estrogen use was significantly more common among younger women, and independent analysis of these factors showed that younger patients had more confined, differentiated cancers, regardless of estrogen use. Of the carcinomas 15.7% were of the adenosquamous variety, but no relationship was observed between estrogen use and this type of cancer. Ten asymptomatic women were first detected with endometrial cancers through routine cervicovaginal cytology. Diabetes mellitus, obesity, thyroid disorders, and personal and family histories of neoplastic disease were found frequently in the patients with endometrial carcinomas. Intensive screening efforts should be directed to highrisk groups to detect these lesions at the earliest opportunity.