Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Barbara Wanjiru Citarella; Christiana Kartsonaki; Elsa D. Ibáñez-Prada; Bronner P. Gonçalves; Joaquin Baruch; Martina Escher; Mark G. Pritchard; Jia Wei; Fred Philippy; Andrew Dagens; Matthew Hall; James Lee; Demetrios James Kutsogiannis; Evert-Jan Wils; Marília Andreia Fernandes; Bharath Kumar Tirupakuzhi Vijayaraghavan; Prasan Kumar Panda; Ignacio Martin-Loeches; Shinichiro Ohshimo; Arie Zainul Fatoni; Peter Horby; Jake Dunning; Jordi Rello; Laura Merson; Amanda Rojek; Michel Vaillant; Piero Olliaro; Luis Felipe Reyes; S.A. Moharam; Sabriya Abdalasalam; Alaa Abdalfattah Abdalhadi; Naana Reyam Abdalla; Walaa Abdalla; Almthani Hamza Abdalrheem; Ashraf Abdalsalam; Saedah Abdeewi; Esraa Hassan Abdelgaum; Mohamed Abdelhalim; Mohammed Abdelkabir; Israa Abdelrahman; Sheryl Ann Abdukahil; Lamees Adil Abdulbaqi; Salaheddin Abdulhamid; Widyan Abdulhamid; Nurul Najmee Abdulkadir; Eman Abdulwahed; Rawad Abdunabi; Ryuzo Abe; Laurent Abel; Ahmed Mohammed Abodina; Amal Abrous; Lara Absil; Kamal Abu Jabal; Nashat Abu Salah; Abdurraouf Abusalama; Tareg Abdallah Abuzaid; Subhash Acharya; Andrew Acker; Elisabeth Adam; Safia Adem; Manuella Ademnou; Francisca Adewhajah; Diana Adrião; Anthony Afum-Adjei Awuah; Melvin Agbogbatey; Saleh Al Ageel; Aya Mustafa Ahmed; Musaab Mohammed Ahmed; Shakeel Ahmed; Zainab Ahmed Alaraji; Abdulrahman Ahmed Elhefnawy Enan; Reham Abdelhamid Ahmed Khalil; Ali Mostafa Ahmed Mohamed Abdelaziz; Kate Ainscough; Eka Airlangga; Tharwat Aisa; Ali Aisha; Bugila Aisha; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Chika Akwani; Eman Al Qasim; Ahmed Alajeeli; Ahmed Alali; Razi Alalqam; Aliya Mohammed Alameen; Mohammed Al-Aquily; Zinah A. Alaraji; Khalid Albakry; Safa Albatni; Angela Alberti; Osama Aldabbourosama; Tala Al-dabbous; Amer Aldhalia; Abdulkarim Aldoukali; Senthilkumar Alegesan; Marta Alessi; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Asil Alflite; Huda Alfoudri; Qamrah Alhadad; Hoda Salem Alhaddad; Maali Khalid Mohamed Abdalla Alhasan; Ahmad Nabil Alhouri; Hasan Alhouri; Adam Ali; Imran Ali; Maha TagElser Mohammed Ali; Syed Ali Abbas; Yomna Ali Abdelghafar; Naseem Ali Sheikh; Kazali Enagnon Alidjnou; Mahmoud Aljadi; Sarah Aljamal; Mohammed Alkahlout; Akram Alkaseek; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; Lana Almasri; Abdulrahman Almjersah; Raja Ahmed Alqandouz; Walaa Alrfaea; Moayad Alrifaee; Rawan Alsaadi; Al-Saba; Heidi J. Dalton

doi:10.1016/j.heliyon.2024.e29591

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Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Journal article

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Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Barbara Wanjiru Citarella, Christiana Kartsonaki, Elsa D. Ibáñez-Prada, Bronner P. Gonçalves, Joaquin Baruch, Martina Escher, Mark G. Pritchard, Jia Wei, Fred Philippy, Andrew Dagens, …

Heliyon, Vol.10(10)

2024

DOI: https://doi.org/10.1016/j.heliyon.2024.e29591

Abstract

Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83–0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders. © 2024 The Authors

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Title: Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
Creators: Barbara Wanjiru Citarella - All India Institute of Medical Sciences Rishikesh
Christiana Kartsonaki - University of Oxford
Elsa D. Ibáñez-Prada - Universidad de La Sabana
Bronner P. Gonçalves - University of Oxford
Joaquin Baruch - University of Oxford
Martina Escher - University of Oxford
Mark G. Pritchard - University of Oxford
Jia Wei - Open Data Institute
Fred Philippy - Luxembourg Institute of Health
Andrew Dagens - University of Oxford
Matthew Hall - University of Oxford
James Lee - University of Oxford
Demetrios James Kutsogiannis - University of Alberta
Evert-Jan Wils
Marília Andreia Fernandes - Hospital Curry Cabral
Bharath Kumar Tirupakuzhi Vijayaraghavan
Prasan Kumar Panda - All India Institute of Medical Sciences Rishikesh
Ignacio Martin-Loeches - St. James's Hospital
Shinichiro Ohshimo - Hiroshima University
Arie Zainul Fatoni - University of Brawijaya
Peter Horby - University of Oxford
Jake Dunning - University of Oxford
Jordi Rello - Centre Hospitalier Universitaire de Nîmes
Laura Merson - University of Oxford
Amanda Rojek - Royal Melbourne Hospital
Michel Vaillant - Luxembourg Institute of Health
Piero Olliaro - University of Oxford
Luis Felipe Reyes - Universidad de La Sabana
S.A. Moharam - All India Institute of Medical Sciences Bhopal
Sabriya Abdalasalam
Alaa Abdalfattah Abdalhadi
Naana Reyam Abdalla
Walaa Abdalla
Almthani Hamza Abdalrheem
Ashraf Abdalsalam
Saedah Abdeewi
Esraa Hassan Abdelgaum
Mohamed Abdelhalim
Mohammed Abdelkabir
Israa Abdelrahman
Sheryl Ann Abdukahil
Lamees Adil Abdulbaqi
Salaheddin Abdulhamid
Widyan Abdulhamid
Nurul Najmee Abdulkadir
Eman Abdulwahed
Rawad Abdunabi
Ryuzo Abe
Laurent Abel
Ahmed Mohammed Abodina
Amal Abrous
Lara Absil
Kamal Abu Jabal
Nashat Abu Salah
Abdurraouf Abusalama
Tareg Abdallah Abuzaid
Subhash Acharya
Andrew Acker - University of Oxford
Elisabeth Adam
Safia Adem
Manuella Ademnou
Francisca Adewhajah
Diana Adrião
Anthony Afum-Adjei Awuah
Melvin Agbogbatey
Saleh Al Ageel
Aya Mustafa Ahmed
Musaab Mohammed Ahmed
Shakeel Ahmed
Zainab Ahmed Alaraji
Abdulrahman Ahmed Elhefnawy Enan
Reham Abdelhamid Ahmed Khalil
Ali Mostafa Ahmed Mohamed Abdelaziz
Kate Ainscough
Eka Airlangga
Tharwat Aisa
Ali Aisha
Bugila Aisha
Ali Ait Hssain
Younes Ait Tamlihat
Takako Akimoto
Ernita Akmal
Chika Akwani
Eman Al Qasim
Ahmed Alajeeli
Ahmed Alali
Razi Alalqam
Aliya Mohammed Alameen
Mohammed Al-Aquily
Zinah A. Alaraji
Khalid Albakry
Safa Albatni
Angela Alberti
Osama Aldabbourosama
Tala Al-dabbous
Amer Aldhalia - University of Oxford
Abdulkarim Aldoukali
Senthilkumar Alegesan
Marta Alessi
Beatrice Alex
Kévin Alexandre
Abdulrahman Al-Fares
Asil Alflite
Huda Alfoudri
Qamrah Alhadad
Hoda Salem Alhaddad
Maali Khalid Mohamed Abdalla Alhasan
Ahmad Nabil Alhouri
Hasan Alhouri
Adam Ali
Imran Ali
Maha TagElser Mohammed Ali
Syed Ali Abbas
Yomna Ali Abdelghafar
Naseem Ali Sheikh
Kazali Enagnon Alidjnou
Mahmoud Aljadi
Sarah Aljamal
Mohammed Alkahlout
Akram Alkaseek
Qabas Alkhafajee
Clotilde Allavena
Nathalie Allou
Lana Almasri
Abdulrahman Almjersah
Raja Ahmed Alqandouz
Walaa Alrfaea
Moayad Alrifaee
Rawan Alsaadi
Al-Saba
Heidi J. Dalton
Publication Details: Heliyon, Vol.10(10)
Publisher: Elsevier Ltd
Identifiers: 991006162975702656
Language: English
Resource Type: Journal article

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

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