Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

P. Martins Simões; J. P. Rasigade; H. Lemriss; M. Butin; C. Ginevra; S. Lemriss; R. V. Goering; A. Ibrahimi; J. C. Picaud; S. El Kabbaj; F. Vandenesch; F. Laurent

doi:10.1128/AAC.01576-13

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Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

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Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A

P. Martins Simões, J. P. Rasigade, H. Lemriss, M. Butin, C. Ginevra, S. Lemriss, R. V. Goering, A. Ibrahimi, J. C. Picaud, S. El Kabbaj, …

Antimicrobial agents and chemotherapy, Vol.57(12), pp.6354-6357

12/2013

DOI: https://doi.org/10.1128/AAC.01576-13

PMCID: PMC3837888

PMID: 24060879

Abstract

Pharmacology

Pharmacology (medical)

Infectious Diseases

Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the NRCS-A strain CR01 harbors a novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies to Staphylococcus aureus ST398 SCCmec and of an SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, and copper. Whole-genome-based comparisons of published S. capitis strains suggest that strain CR01 acquired the two elements independently.

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Title: Characterization of a novel composite staphylococcal cassette chromosome mec (SCCmec-SCCcad/ars/cop) in the neonatal sepsis-associated Staphylococcus capitis pulsotype NRCS-A
Creators: P. Martins Simões (Author) - IPN-Lyon;Hospices Civils de Lyon-Centre Léon Bérard
J. P. Rasigade (Author) - IPN-Lyon;Hospices Civils de Lyon-Centre Léon Bérard
H. Lemriss (Author) - Medical Analysis of the Fraternal of Gendarmerie Royale;Mohammed V University in Rabat
M. Butin (Author) - IPN-Lyon;Hospices Civils de Lyon-Centre Léon Bérard
C. Ginevra (Author) - IPN-Lyon
S. Lemriss (Author) - Medical Analysis of the Fraternal of Gendarmerie Royale
R. V. Goering (Author) - Department of Medical Microbiology and Immunology
A. Ibrahimi (Author) - Mohammed V University in Rabat
J. C. Picaud (Author) - Hospices Civils de Lyon-Centre Léon Bérard
S. El Kabbaj (Author) - Medical Analysis of the Fraternal of Gendarmerie Royale
F. Vandenesch (Author) - IPN-Lyon;Hospices Civils de Lyon-Centre Léon Bérard
F. Laurent (Author) - IPN-Lyon;Hospices Civils de Lyon-Centre Léon Bérard
Publication Details: Antimicrobial agents and chemotherapy, Vol.57(12), pp.6354-6357
Series: 57
Number of pages: 4
Identifiers: 991005929000802656
Academic Unit: Med. Microbiology & Immunology
Language: English
Resource Type: Journal article