Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

Heng Xu; Giles W. Robinson; Jie Huang; Joshua Yew Suang Lim; Hui Zhang; Johnnie K. Bass; Alberto Broniscer; Murali Chintagumpala; Ute Bartels; Sri Gururangan; Tim Hassall; Michael Fisher; Richard Cohn; Tetsuji Yamashita; Tal Teitz; Jian Zuo; Arzu Onar-Thomas; Amar Gajjar; Clinton F. Stewart; Jun J. Yang

doi:10.1038/ng.3217

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Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

Journal article

Peer reviewed

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

Heng Xu, Giles W. Robinson, Jie Huang, Joshua Yew Suang Lim, Hui Zhang, Johnnie K. Bass, Alberto Broniscer, Murali Chintagumpala, Ute Bartels, Sri Gururangan, …

Nature genetics, Vol.47(3), pp.263-266

02/25/2015

DOI: https://doi.org/10.1038/ng.3217

PMCID: PMC4358157

PMID: 25665007

Abstract

Genetics

Taking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10 -8, hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, with independent replication in 68 similarly treated children. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. These results point to new biology underlying the ototoxic effects of platinum agents.

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Title: Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss
Creators: Heng Xu (Author) - St. Jude Children Research Hospital;Sichuan University
Giles W. Robinson (Author) - St. Jude Children Research Hospital
Jie Huang (Author) - St. Jude Children Research Hospital
Joshua Yew Suang Lim (Author) - St. Jude Children Research Hospital;National University of Singapore
Hui Zhang (Author) - St. Jude Children Research Hospital
Johnnie K. Bass (Author) - St. Jude Children Research Hospital
Alberto Broniscer (Author) - St. Jude Children Research Hospital
Murali Chintagumpala (Author) - Baylor College of Medicine
Ute Bartels (Author) - University of Toronto
Sri Gururangan (Author) - Duke University
Tim Hassall (Author) - Royal Children's Hospital, Melbourne
Michael Fisher (Author) - University of Pennsylvania
Richard Cohn (Author) - University of New South Wales
Tetsuji Yamashita (Author) - St. Jude Children Research Hospital
Tal Teitz (Author) - St. Jude Children Research Hospital
Jian Zuo (Author) - St. Jude Children Research Hospital
Arzu Onar-Thomas (Author) - St. Jude Children Research Hospital
Amar Gajjar (Author) - St. Jude Children Research Hospital
Clinton F. Stewart (Author) - St. Jude Children Research Hospital
Jun J. Yang (Author) - St. Jude Children Research Hospital
Additional links: Bisgin, Halil; Thomson, Robert; Hyder, Ayaz; Dancy, Christopher; Barnaghi, Payam; Gottlob, Georg; Katsaros, Dimitrios; Manolopoulos, Yannis; Pandey, Rahul; Tzouramanis, Theodoros; Vakali, Athena
Publication Details: Nature genetics, Vol.47(3), pp.263-266
Series: 47
Number of pages: 4
Identifiers: 991005930499402656
Academic Unit: Creighton University
Language: English
Resource Type: Journal article

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss

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