Abstract
The authors showed previously that subtypes of alpha sub(1)-adrenergic receptors can be differentiated by selective inactivation with chlorethylclonidine (CEC) or by their affinities for the competitive antagonist WB 4101. The results suggest that: the CEC-sensitive and -insensitive super(125)IBE 2254: super(125)I-(2- beta -(4-hydroxyphenyl)-ethylaminomethyl)-tetralone binding sites are equivalent to those with a low and high affinity for WB 4101, respectively, and the CEC-sensitive binding sites with a low affinity for WB 4101 are the alpha sub(1)-adrenergic receptors linked to inositol phospholipid hydrolysis.