Abstract
Twenty-nine rabbits were studied to evaluate the relative accuracy of creatinine clearance in the estimation of glomerular filtration rate, compared with inulin clearance, in a partially obstructed kidney. Partial unilateral ureteral obstruction was created by burying a segment of the proximal portion of the ureter in the psoas muscle in 21 rabbits. After variable periods of observation, the clearance procedures were performed. Eight rabbits were used as controls. The method used for creation of obstruction induced gross and microscopic changes compatible with partial obstruction. Mean differential glomerular filtration rate measured by both methods correlated well in nonobstructed and obstructed kidneys.