Abstract
Acute sleep deprivation impairs cognitive, psychomotor, and mood outcomes, in part by reducing cerebral adenosine triphosphate (ATP) availability. Creatine supplementation may counter these effects by increasing phosphocreatine stores.
Six databases were systematically searched (January 2006-May 2025) for studies investigating creatine's effects on cognitive, psychomotor, and mood outcomes during acute sleep deprivation.
Results were synthesized narratively. Of 160 records, five studies met the inclusion criteria. Early investigations indicate a positive trend for creatine supplementation as an intervention for acute sleep deprivation, though effects may vary by cognitive domain.
Despite favorable early results, research is sparse, and future high-quality trials are needed.