DNA-catalyzed glycosylation using aryl glycoside donors

Anthony R. Hesser; Benjamin M. Brandsen; Shannon M. Walsh; Puzhou Wang; Scott K. Silverman

doi:10.1039/c6cc04329a

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DNA-catalyzed glycosylation using aryl glycoside donors

Journal article

Open access

Peer reviewed

DNA-catalyzed glycosylation using aryl glycoside donors

Anthony R. Hesser, Benjamin M. Brandsen, Shannon M. Walsh, Puzhou Wang and Scott K. Silverman

Chemical Communications, Vol.52(59), pp.9259-9262

2016

DOI: https://doi.org/10.1039/c6cc04329a

PMID: 27355482

Abstract

Catalysis

Electronic, Optical and Magnetic Materials

Ceramics and Composites

Chemistry(all)

Surfaces, Coatings and Films

Metals and Alloys

Materials Chemistry

We report the identification by in vitro selection of Zn2+/Mn2+-dependent deoxyribozymes that glycosylate the 3′-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.

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Title: DNA-catalyzed glycosylation using aryl glycoside donors
Creators: Anthony R. Hesser (Author) - University of Illinois at Urbana-Champaign
Benjamin M. Brandsen (Author) - University of Illinois at Urbana-Champaign
Shannon M. Walsh (Author) - University of Illinois at Urbana-Champaign
Puzhou Wang (Author) - University of Illinois at Urbana-Champaign
Scott K. Silverman (Author) - University of Illinois at Urbana-Champaign
Publication Details: Chemical Communications, Vol.52(59), pp.9259-9262
Series: 52
Number of pages: 4
Grant note: This work was supported by a grant to S. K. S. from the National Institutes of Health (R01GM065966). B. M. B. was partially supported by NIH T32GM070421. S. M. W. was partially supported by an NIH predoctoral fellowship (F31GM115147). Mass spectrometry was performed at the UIUC School of Chemical Sciences Mass Spectrometry Laboratory on an instrument purchased with support from NIH grant S10RR027109A.
Identifiers: 991005929864302656
Academic Unit: Creighton University
Language: English
Resource Type: Journal article