Abstract
e16288 Background: Gastric carcinoid tumors, previously known as neuroendocrine neoplasms, are derived from enterochromaffin cells and show an increasing incidence globally. Neuroendocrine tumors often result in hormonal syndromes due to the production of exogenous hormonal peptides by the tumor. Current treatment options include surgical resection and somatostatin pharmacotherapy to blunt tumor growth. A gastric carcinoid malignancy that requires more investigation is enterochromaffin cell carcinoid (ECC). Considering the increasing incidence of gastric carcinoids, a retrospective investigation of demographic data involving enterochromaffin cell carcinoids was performed using the National Cancer Database (NCDB). Methods: The 2004-2019 NCDB was explored to perform a retrospective cohort analysis of patients diagnosed with ECC. 200 patients with a histologically confirmed diagnosis (ICD-O-3 code 8241/3) were identified. Descriptive statistics were used to analyze the following demographic data of patients in this study: race, sex, age, income quartile, facility type, Hispanic status, and Chales/Deyo score. Regression analysis was used to interpret incidence trends. Results: The NCDB identified 200 patients diagnosed with ECC from 2004-2019 with incidence rates varying over this time (R² = 0.0001). The mean age at diagnosis was 55 years (SD = 19.7, range = 14-90). Women (62%) were more likely to be diagnosed than men. The majority of patients were White (86%) and non-Hispanic (80%). Most patients (99.9%) received treatment for the remission of the cancer, predominantly through surgical means (86.5%). More patients were treated in an Comprehensive Community Cancer program (34.5%) than in an academic/research program (26.0%). The majority of individuals lived in metropolitan counties with a population greater than 1 million (54%) than in other metropolitan counties (22%). Most patients were in the fourth quartile of income earners (32.1%). The top primary site was the appendix (40.5%), and most individuals (79.5%) had Charles/Deyo comorbidity scores of 0. Conclusions: To the best of our understanding, this is the first NCDB investigation of Enterochromaffin Cell Carcinoid (ECC) and therefore addresses a meaningful educational disparity on the topic. Most ECC patients tend to be White, non-Hispanic individuals with a primary diagnosis site of the appendix, consistent with previous studies. Upon analyzing the socioeconomic factors of ECC patients, it was found that they often fall into the top income quartile, live in densely populated metropolitan counties, and receive treatment from a comprehensive community cancer program. Due to the significance of these demographic and socioeconomic factors, more research is needed to understand their impact on the diagnosis and treatment of ECC.