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Development of daptomycin resistance in a bone marrow transplant patient with vancomycin-resistant Enterococcus durans
Journal article   Peer reviewed

Development of daptomycin resistance in a bone marrow transplant patient with vancomycin-resistant Enterococcus durans

Myke R. Green, Claudio Anasetti, Ramon L. Sandin, Nancy E. Rolfe and John N. Greene
Journal of Oncology Pharmacy Practice, Vol.12(3)
2006
DOI: https://doi.org/10.1177/1078155206069165

Abstract

Bone Marrow Transplantation Daptomycin Drug Resistance, Multiple, Bacterial Enterococcus Female Gram-Positive Bacterial Infections Humans Middle Aged Vancomycin Vancomycin Resistance calcium ion cefepime daptomycin levofloxacin linezolid mycophenolic acid 2 morpholinoethyl ester prednisone vancomycin adult antibiotic resistance article bacteremia bacterial colonization bacterium detection blood culture bone marrow transplantation case report catheter removal clinical feature colony forming unit drug substitution Enterococcus durans female graft versus host reaction hemodialysis human hypotension kidney disease Klebsiella pneumoniae minimum inhibitory concentration myelofibrosis priority journal Pseudomonas aeruginosa sensitivity analysis treatment response urine culture vancomycin resistant Enterococcus
Daptomycin has demonstrated antibacterial activity against several antibiotic-resistant strains, including vancomycin-resistant enterococci. A paucity of data exists concerning in vivo development of daptomycin resistance of enterococci. We describe an allogeneic bone marrow transplant patient, who was found to have vancomycin-resistant Enterococcus durans bacteremia, which subsequently developed resistance to daptomycin. © 2006 SAGE Publications.

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