Abstract
Rheumatoid arthritis (RA) is a chronic, progressive, inflammatory condition that affects about 1% of the world's population. The multifactorial nature of RA has created continuous research discoveries leading to improved identification of specific pathways for the pathogenesis of RA. Improved understanding of the pathways has allowed the development of new targeted drugs. Clinicians must understand the most common pathways for pathogenesis of RA, proper diagnostic techniques, and the appropriate management of this disease given the many possible options at their disposal. © 2021 American Academy of Physician Assistants.