Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an NTRK2 Fusion: The Impact of Integrated Genomic Profiling

Ross Mangum; Jacquelyn Reuther; Kelsey C Bertrand; Raghu Chandramohan; Marcia K Kukreja; Arnold C Paulino; Donna Muzny; Jianhong Hu; Richard A Gibbs; Daniel J Curry; Fatema Malbari; Murali M Chintagumpala; Adekunle M Adesina; Kevin E Fisher; Stephen C Mack; Sharon E Plon; Angshumoy Roy; D Williams Parsons; Frank Y Lin

doi:10.1200/PO.20.00375

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Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an NTRK2 Fusion: The Impact of Integrated Genomic Profiling

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Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an NTRK2 Fusion: The Impact of Integrated Genomic Profiling

Ross Mangum, Jacquelyn Reuther, Kelsey C Bertrand, Raghu Chandramohan, Marcia K Kukreja, Arnold C Paulino, Donna Muzny, Jianhong Hu, Richard A Gibbs, Daniel J Curry, …

JCO precision oncology, Vol.5(5), pp.1221-1227

2021

DOI: https://doi.org/10.1200/PO.20.00375

PMID: 34651095

Abstract

Brain Neoplasms - drug therapy

Brain Neoplasms - genetics

Brain Neoplasms - pathology

Child

Ependymoma - drug therapy

Ependymoma - genetics

Ependymoma - pathology

Gene Expression Profiling

Humans

Male

Membrane Glycoproteins - genetics

Neoplasm Recurrence, Local

Pyrazoles - therapeutic use

Pyrazoles - urine

Pyrimidines - therapeutic use

Pyrimidines - urine

Receptor, trkB - genetics

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Title: Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an NTRK2 Fusion: The Impact of Integrated Genomic Profiling
Creators: Ross Mangum - Baylor College of Medicine
Jacquelyn Reuther - Baylor College of Medicine
Kelsey C Bertrand - Baylor College of Medicine
Raghu Chandramohan - Baylor College of Medicine
Marcia K Kukreja - Texas Children's Hospital
Arnold C Paulino - The University of Texas MD Anderson Cancer Center
Donna Muzny - Baylor College of Medicine
Jianhong Hu - Baylor College of Medicine
Richard A Gibbs - Baylor College of Medicine
Daniel J Curry - Baylor College of Medicine
Fatema Malbari - Texas Children's Hospital
Murali M Chintagumpala - Baylor College of Medicine
Adekunle M Adesina - Baylor College of Medicine
Kevin E Fisher - Texas Children's Hospital
Stephen C Mack - Baylor College of Medicine
Sharon E Plon - Baylor College of Medicine
Angshumoy Roy - Baylor College of Medicine
D Williams Parsons - Baylor College of Medicine
Frank Y Lin - Baylor College of Medicine
Publication Details: JCO precision oncology, Vol.5(5), pp.1221-1227
Identifiers: 991006262516002656
Academic Unit: Pediatrics
Language: English
Resource Type: Journal article