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Effects of Cigarette Smoke Extract and Nicotine on Regulator of G Protein Signaling-2 Expression in Human Airway Smooth Muscle and Bronchial Epithelial Cells
Journal article   Open access  Peer reviewed

Effects of Cigarette Smoke Extract and Nicotine on Regulator of G Protein Signaling-2 Expression in Human Airway Smooth Muscle and Bronchial Epithelial Cells

Farnaz Tabatabaian, Michael Teng, Kim Tran, Diane Allen-Gipson, Zhi Tian, Richard Lockey, Yan Xie, Yaping Tu and Thomas Casale
Journal of allergy and clinical immunology, Vol.135(2), pp.AB227-AB227
02/01/2015
DOI: https://doi.org/10.1016/j.jaci.2014.12.1675

Abstract

Asthma Cigarettes Nicotine Proteins Smooth muscle
Conclusions Our data suggest that acute exposure of HASM or HBEC to CSE, at either high or low doses does not significantly alter RGS2 expression, in contrast with chronic low dose exposure in HASM. Since RGS2 regulates airway hyperresponsiveness and controls many important epithelial and smooth muscle cell functions, further study on the effects of cigarette smoke and/or nicotine on airway RGS2 expression and function are warranted.
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https://doi.org/10.1016/j.jaci.2014.12.1675View
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