Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease

Carla N Budrow; Luis-Daniel Bernal-Conde; Ivette M Sandoval; Ashley Galfano; Han Grezenko; Angela Velazquez; David J Marmion; Eden Flores-Barrera; Shruti Venkatesh; Michael Coyle; Kimberly Meyers; Kayla Nguyen; Hannah Holden; Kuei Yuan Tseng; Christopher R Bishop; Fredric P Manfredsson

doi:10.1186/s40478-026-02221-1

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Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease

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Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease

Carla N Budrow, Luis-Daniel Bernal-Conde, Ivette M Sandoval, Ashley Galfano, Han Grezenko, Angela Velazquez, David J Marmion, Eden Flores-Barrera, Shruti Venkatesh, Michael Coyle, …

Acta neuropathologica communications

03/11/2026

DOI: https://doi.org/10.1186/s40478-026-02221-1

PMID: 41814449

Abstract

Adeno-associated virus (AAV)

Chemogenetics

Serotonin (5-HT)

Designer receptors exclusively activated by designer drugs (DREADDs)

Electrophysiology

Parkinson’s disease (PD)

6-OHDA lesion

L-DOPA-induced dyskinesia (LID)

TPH-CRE

Raphe-striatal

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Title: Effects of chemogenetic inhibition of serotonergic raphe-striatal neurons on L-DOPA-induced behaviors and neurochemistry in a rat model of Parkinson's disease
Creators: Carla N Budrow - Binghamton University
Luis-Daniel Bernal-Conde - Barrow Neurological Institute
Ivette M Sandoval - Barrow Neurological Institute
Ashley Galfano - Binghamton University
Han Grezenko - Barrow Neurological Institute
Angela Velazquez - Barrow Neurological Institute
David J Marmion - Barrow Neurological Institute
Eden Flores-Barrera - University of Illinois Chicago
Shruti Venkatesh - Binghamton University
Michael Coyle - Binghamton University
Kimberly Meyers - Barrow Neurological Institute
Kayla Nguyen - Barrow Neurological Institute
Hannah Holden - Binghamton University
Kuei Yuan Tseng - University of Illinois Chicago
Christopher R Bishop - Binghamton University
Fredric P Manfredsson - Barrow Neurological Institute
Publication Details: Acta neuropathologica communications
Grant note: R01NS122226 / NIH National Institute of Neurological Disorders and Stroke
Identifiers: 991006262931402656
Academic Unit: Surgery
Language: English
Resource Type: Journal article