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Enantiocontrolled synthesis of (S)-3-substituted cycloalkanones from (s)-2-(p-tolylsulfinyl)-2-cycloalkenones and diorganomagnesium reagents.
Journal article   Peer reviewed

Enantiocontrolled synthesis of (S)-3-substituted cycloalkanones from (s)-2-(p-tolylsulfinyl)-2-cycloalkenones and diorganomagnesium reagents.

Gary H. Posner and Martin Hulce
Tetrahedron Letters, Vol.25(4), pp.379-382
25
1984

Abstract

Biochemistry Drug Discovery Organic Chemistry
By appropriate choice of reaction conditions, the same enantiomerically pure (S)-(+)-2-(p-tolylsulfinyl)cycloalkenone can be converted into either an (R)-or an (S)-3-substituted cycloalkanone in good to excellent enantiomeric purity.

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