Genetic determinants of serum testosterone concentrations in men

Claes Ohlsson; Henri Wallaschofski; Kathryn L. Lunetta; Lisette Stolk; John R.B. Perry; Annemarie Koster; Ann Kristin Petersen; Joel Eriksson; Terho Lehtimäki; Ilpo T. Huhtaniemi; Geoffrey L. Hammond; Marcello Maggio; Andrea D. Coviello; Study Group Emas Study Group; Luigi Ferrucci; Margit Heier; Albert Hofman; Kate L. Holliday; John Olov Jansson; Mika Kähönen; David Karasik; Magnus K. Karlsson; Douglas P. Kiel; Yongmei Liu; Östen Ljunggren; Mattias Lorentzon; Leo Pekka Lyytikäinen; Thomas Meitinger; Dan Mellström; David Melzer; Iva Miljkovic; Matthias Nauck; Maria Nilsson; Brenda Penninx; Stephen R. Pye; Ramachandran S. Vasan; Martin Reincke; Fernando Rivadeneira; Abdelouahid Tajar; Alexander Teumer; André G. Uitterlinden; Jagadish Ulloor; Jorma Viikari; Uwe Völker; Henry Völzke; H. Erich Wichmann; Tsung Sheng Wu; Wei Vivian Zhuang; Elad Ziv; Frederick C.W. Wu; Olli Raitakari; Anna Eriksson; Martin Bidlingmaier; Tamara B. Harris; Anna Murray; Frank H. de Jong; Joanne M. Murabito; Shalender Bhasin; Liesbeth Vandenput; Robin Haring

doi:10.1371/journal.pgen.1002313

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Genetic determinants of serum testosterone concentrations in men

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Genetic determinants of serum testosterone concentrations in men

Claes Ohlsson, Henri Wallaschofski, Kathryn L. Lunetta, Lisette Stolk, John R.B. Perry, Annemarie Koster, Ann Kristin Petersen, Joel Eriksson, Terho Lehtimäki, Ilpo T. Huhtaniemi, …

PLoS genetics, Vol.7(10), e1002313

10/2011

DOI: https://doi.org/10.1371/journal.pgen.1002313

PMCID: PMC3188559

PMID: 21998597

Abstract

Ecology, Evolution, Behavior and Systematics

Molecular Biology

Genetics

Genetics(clinical)

Cancer Research

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as -41 and rs6258, p = 2.3×10 -22). Subjects with ≥3 risk alleles of these variants had 6.5-fold higher risk of having low serum testosterone than subjects with no risk allele. The rs5934505 polymorphism near FAM9B on the X chromosome was also associated with testosterone concentrations (p = 5.6×10 -16). The rs6258 polymorphism in exon 4 of SHBG affected SHBG's affinity for binding testosterone and the measured free testosterone fraction (p

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Title: Genetic determinants of serum testosterone concentrations in men
Creators: Claes Ohlsson (Author) - University of Gothenburg
Henri Wallaschofski (Author) - University of Greifswald
Kathryn L. Lunetta (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Lisette Stolk (Author) - Erasmus University Rotterdam;Netherlands Consortium of Healthy Ageing
John R.B. Perry (Author) - University of Exeter;University of Oxford
Annemarie Koster (Author) - National Institutes of Health
Ann Kristin Petersen (Author) - Helmholtz Zentrum München - German Research Center for Environmental Health
Joel Eriksson (Author) - University of Gothenburg
Terho Lehtimäki (Author) - Tampere University
Ilpo T. Huhtaniemi (Author) - Imperial College London
Geoffrey L. Hammond (Author) - University of British Columbia
Marcello Maggio (Author) - University of Parma
Andrea D. Coviello (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Study Group Emas Study Group (Author) - University of Manchester
Luigi Ferrucci (Author) - National Institutes of Health
Margit Heier (Author) - Helmholtz Zentrum München - German Research Center for Environmental Health
Albert Hofman (Author) - Netherlands Consortium of Healthy Ageing;Erasmus University Rotterdam
Kate L. Holliday (Author) - University of Manchester
John Olov Jansson (Author) - University of Gothenburg
Mika Kähönen (Author) - Tampere University
David Karasik (Author) - Harvard University
Magnus K. Karlsson (Author) - Lund University
Douglas P. Kiel (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Harvard University
Yongmei Liu (Author) - Wake Forest University
Östen Ljunggren (Author) - Uppsala University
Mattias Lorentzon (Author) - University of Gothenburg
Leo Pekka Lyytikäinen (Author) - Tampere University
Thomas Meitinger (Author) - Technical University of Munich;Helmholtz Zentrum München - German Research Center for Environmental Health
Dan Mellström (Author) - University of Gothenburg
David Melzer (Author) - University of Exeter
Iva Miljkovic (Author) - University of Pittsburgh
Matthias Nauck (Author) - University of Greifswald
Maria Nilsson (Author) - University of Gothenburg
Brenda Penninx (Author) - VU Medical Center
Stephen R. Pye (Author) - University of Manchester
Ramachandran S. Vasan (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Martin Reincke (Author) - Ludwig Maximilian University of Munich
Fernando Rivadeneira (Author) - Erasmus University Rotterdam;Netherlands Consortium of Healthy Ageing
Abdelouahid Tajar (Author) - University of Manchester
Alexander Teumer (Author) - University of Greifswald
André G. Uitterlinden (Author) - Erasmus University Rotterdam;Netherlands Consortium of Healthy Ageing
Jagadish Ulloor (Author) - Boston University
Jorma Viikari (Author) - University of Turku
Uwe Völker (Author) - University of Greifswald
Henry Völzke (Author) - University of Greifswald
H. Erich Wichmann (Author) - Ludwig Maximilian University of Munich;Helmholtz Zentrum München - German Research Center for Environmental Health
Tsung Sheng Wu (Author) - University of British Columbia
Wei Vivian Zhuang (Author) - Public Health
Elad Ziv (Author) - University of California at San Francisco
Frederick C.W. Wu (Author) - University of Manchester
Olli Raitakari (Author) - University of Turku
Anna Eriksson (Author) - University of Gothenburg
Martin Bidlingmaier (Author) - Ludwig Maximilian University of Munich
Tamara B. Harris (Author) - National Institutes of Health
Anna Murray (Author) - University of Exeter;University of Oxford
Frank H. de Jong (Author) - Erasmus University Rotterdam
Joanne M. Murabito (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Shalender Bhasin (Author) - National Heart, Lung, and Blood Institute's The Framingham Heart Study;Boston University
Liesbeth Vandenput (Author) - University of Gothenburg
Robin Haring (Author) - University of Greifswald
Publication Details: PLoS genetics, Vol.7(10), e1002313
Series: 7
Identifiers: 991005929733802656
Academic Unit: Master Public Health
Language: English
Resource Type: Journal article