We thank T. Brown for assistance in editing this manuscript. This work was supported by grants from the Simons Foundation (SFARI 336475 to E.E.E.), National Institute of Child Health and Development (HHSN267200700021C to J.M.S.), (HHSN275200800015C and HHSN267200700023C to E.M.F.), National Institute of Neurological Disorders and Stroke (NS062972 to A.S.M.), National Institute of General Medical Sciences (predoctoral training grant 5T32GM07814 to P.W.H.), and National Human Genome Research Institute (postdoctoral training grant 2T32HG000035 to T.N.T.). We also thank Dr. Daniela Witten for advice on statistical testing of regulatory elements and Dr. Bradley Coe for information on CNVs from his previous publication. We thank Natalia Volfovsky, Alex Lash, and Malcolm Mallardi from the Simons Foundation for help with depositing genome data to SFARI Base and Colleen Davis for help with depositing genome data to dbGaP. We are grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, and E. Wijsman). We appreciate receiving access to phenotypic data on Simons Foundation Autism Research Initiative (SFARI) Base. Approved researchers can obtain the SSC population dataset described in this study by applying at SFARI Base (see Web Resources ). E.E.E. is an investigator of the Howard Hughes Medical Institute.
Funding Information:
We thank T. Brown for assistance in editing this manuscript. This work was supported by grants from the Simons Foundation (SFARI 336475 to E.E.E.), National Institute of Child Health and Development (HHSN267200700021C to J.M.S.), (HHSN275200800015C and HHSN267200700023C to E.M.F.), National Institute of Neurological Disorders and Stroke (NS062972 to A.S.M.), National Institute of General Medical Sciences (predoctoral training grant 5T32GM07814 to P.W.H.), and National Human Genome Research Institute (postdoctoral training grant 2T32HG000035 to T.N.T.). We also thank Dr. Daniela Witten for advice on statistical testing of regulatory elements and Dr. Bradley Coe for information on CNVs from his previous publication. We thank Natalia Volfovsky, Alex Lash, and Malcolm Mallardi from the Simons Foundation for help with depositing genome data to SFARI Base and Colleen Davis for help with depositing genome data to dbGaP. We are grateful to all of the families at the participating Simons Simplex Collection (SSC) sites, as well as the principal investigators (A. Beaudet, R. Bernier, J. Constantino, E. Cook, E. Fombonne, D. Geschwind, R. Goin-Kochel, E. Hanson, D. Grice, A. Klin, D. Ledbetter, C. Lord, C. Martin, D. Martin, R. Maxim, J. Miles, O. Ousley, K. Pelphrey, B. Peterson, J. Piggot, C. Saulnier, M. State, W. Stone, J. Sutcliffe, C. Walsh, Z. Warren, and E. Wijsman). We appreciate receiving access to phenotypic data on Simons Foundation Autism Research Initiative (SFARI) Base. Approved researchers can obtain the SSC population dataset described in this study by applying at SFARI Base (see Web Resources). E.E.E. is an investigator of the Howard Hughes Medical Institute.