Abstract
Experiments were conducted to determine if the modulation of the febrile and cytokine responses of rats by glucocorticoids is caused by the elevation of this stress hormone or by its permissive effects. This involved the administration of varying doses of replacement corticosterone to adrenaloctomized (ADX) rats. The febrile response of ADX rats were compared to those of sham-ADX rats provided with placebo pellets. Results indicate that changes in intact rats due to glucocorticoids are not permissive.