Abstract
BackgroundCD4+ T-lymphocytopenia immunodeficiency without human immunodeficiency virus (HIV) infection has been reported recently. The association between immunodeficiency and anogenital neoplasia secondary to human papillomavirus infections is well documented.CaseA woman with recurrent vulvar intraepithelial neoplasia (VIN) had idiopathic CD4+ T-lymphocytopenia without HIV infection.ConclusionHuman papillomavirus-related VIN may be associated with idiopathic CD4+ T-lymphocytopenia.