Identification of a BRCA2-Specific Modifier                      Locus at 6p24 Related to Breast Cancer Risk

Mia M. Gaudet; Karoline B. Kuchenbaecker; Joseph Vijai; Robert J. Klein; Tomas Kirchhoff; Lesley McGuffog; Daniel Barrowdale; Alison M. Dunning; Andrew Lee; Joe Dennis; Sue Healey; Ed Dicks; Penny Soucy; Olga M. Sinilnikova; Vernon S. Pankratz; Xianshu Wang; Ronald C. Eldridge; Daniel C. Tessier; Daniel Vincent; Francois Bacot; Frans B.L. Hogervorst; Susan Peock; Dominique Stoppa-Lyonnet; Florence Coulet; Chrystelle Colas; Florent Soubrier; Paolo Peterlongo; Rita K. Schmutzler; Katherine L. Nathanson; Marion Piedmonte; Christian F. Singer; Mads Thomassen; Johanna Sokolowska; Myriam Bronner; Thomas V.O. Hansen; Susan L. Neuhausen; Ignacio Blanco; Mark H. Greene; Judith Garber; Jeffrey N. Weitzel; Irene L. Andrulis; David E. Goldgar; Emma D'Andrea; Trinidad Caldes; Heli Nevanlinna; Ana Osorio; Elizabeth J. van Rensburg; Adalgeir Arason; Gad Rennert; Ans M.W. van den Ouweland; Annemarie H. van der Hout; Carolien M. Kets; Cora M. Aalfs; Juul T. Wijnen; Margreet G.E.M. Ausems; Debra Frost; Steve Ellis; Elena Fineberg; Radka Platte; D. Gareth Evans; Chris Jacobs; Julian Adlard; Marc Tischkowitz; Mary E. Porteous; Francesca Damiola; Lisa Golmard; Laure Barjhoux; Michel Longy; Muriel Belotti; Sandra Fert Ferrer; Sylvie Mazoyer; Amanda B. Spurdle; Siranoush Manoukian; Monica Barile; Maurizio Genuardi; Norbert Arnold; Alfons Meindl; Christian Sutter; Barbara Wappenschmidt; Susan M. Domchek; Georg Pfeiler; Eitan Friedman; Uffe Birk Jensen; Mark Robson; Sohela Shah; Conxi Lazaro; Phuong L. Mai; Javier Benitez; Melissa C. Southey; M. K. Schmidt; Peter A. Fasching; Julian Peto; Manjeet K. Humphreys; Qin Wang; Kyriaki Michailidou; Elinor J. Sawyer; Barbara Burwinkel; Pascal Guénel; Stig E. Bojesen; Roger L. Milne; Hermann Brenner; Magdalena Lochmann; Hiltrud Brauch; Yon Dschun Ko; Christian Baisch; Hand Peter Fischer; Thomas Bruening; Beate Pesch; Sylvia Rabstein; Anne Spickenheuer; Kristiina Aittomäki; Thilo Dörk; Sara Margolin; Arto Mannermaa; Diether Lambrechts; Jenny Chang-Claude; Paolo Radice; Graham G. Giles; Christopher A. Haiman; Robert Winqvist; Peter Devillee; Montserrat García-Closas; Nils Schoof; M. J. Hooning; Angela Cox; Paul D.P. Pharoah; Anna Jakubowska; Nick Orr; Anna González-Neira; Guillermo Pita; M. Rosario Alonso; Per Hall; Fergus J. Couch; Jacques Simard; David Altshuler; Douglas F. Easton; Georgia Chenevix-Trench; Antonis C. Antoniou; Kenneth Offit; M. A. Rookus; F. E. van Leeuwen; S. Verhoef; J. L. de Lange; J. M. Collée; C. Seynaeve; C. H.M. van Deurzen; C. J. van Asperen; R. A. Tollenaar; P. Devilee; T. C.T.E.F. van Cronenburg; A. R. Mensenkamp; R. B. van der Luijt; T. A.M. van Os; J. J.P. Gille; Q. Waisfisz; H. E.J. Meijers-Heijboer; E. B. Gómez-Garcia; M. J. Blok; J. C. Oosterwijk; M. J. Mourits; G. H. de Bock; H. F. Vasen; Zosia Miedzybrodzka; Helen Gregory; Patrick Morrison; Lisa Jeffers; Trevor Cole; Kai ren Ong; Jonathan Hoffman; Alan Donaldson; Margaret James; Joan Paterson; Amy Taylor; Alexandra Murray; Mark T. Rogers; Emma McCann; M. John Kennedy; David Barton; Mary Porteous; Sarah Drummond; Carole Brewer; Emma Kivuva; Anne Searle; Selina Goodman; Kathryn Hill; Rosemarie Davidson; Victoria Murday; Nicola Bradshaw; Lesley Snadden; Mark Longmuir; Catherine Watt; Sarah Gibson; Eshika Haque; Ed Tobias; Alexis Duncan; Louise Izatt; Caroline Langman; Angela Brady; Huw Dorkins; Athalie Melville; Kashmir Randhawa; Julian Barwell; Gemma Serra-Feliu; Ian Ellis; Catherine Houghton; Fiona Lalloo; Jane Taylor; Lucy Side; Alison Male; Cheryl Berlin; Jacqueline Eason; Fiona Douglas; Oonagh Claber; Rebecca Collier; Irene Jobson; Lisa Walker; Diane McLeod; Sarah Durell; Barbara Stayner; Rosalind A. Eeles; Susan Shanley; Nazneen Rahman; Richard Houlston; Elizabeth Bancroft; Elizabeth Page; Audrey Ardern-Jones; Kelly Kohut; Jennifer Wiggins; Elena Castro; Emma Killick; Sue Martin; Gillian Rea; Anjana Kulkarni; Jackie Cook; Oliver Quarrell; Cathryn Bardsley; Shirley Hodgson; Sheila Goff; Glen Brice; Lizzie Winchester; Charlotte Eddy; Vishakha Tripathi; Virginia Attard; Anna Lehmann; Diana Eccles; Anneke Lucassen; Gillian Crawford; Donna McBride; Sarah Smalley; Olga Sinilnikova; Carole Verny-Pierre; Sophie Giraud; Mélanie Léone; Marion Gauthier-Villars; Bruno Buecher; Claude Houdayer; Virginie Moncoutier; Carole Tirapo; Antoine de Pauw; Brigitte Bressac-de-Paillerets; Olivier Caron; Yves Jean Bignon; Nancy Uhrhammer; Christine Lasset; Valérie Bonadona; Sandrine Handallou; Agnés Hardouin; Pascaline Berthet; Hagay Sobol; Violaine Bourdon; Tetsuro Noguchi; Audrey Remenieras; Isabelle Coupier; Pascal Pujol; Jean Philippe Peyrat; Joëlle Fournier; Françoise Révillion; Philippe Vennin; Claude Adenis; Etienne Rouleau; Rosette Lidereau; Liliane Demange; Catherine Nogues; Danièle Muller; Jean Pierre Fricker; Emmanuelle Barouk-Simonet; Françoise Bonnet; Virginie Bubien; Nicolas Sevenet; Christine Toulas; Rosine Guimbaud; Laurence Gladieff; Viviane Feillel; Hélène Dreyfus; Christine Rebischung; Magalie Peysselon; Fanny Coron; Laurence Faivre; Fabienne Prieur; Marine Lebrun; Caroline Kientz; Marc Frénay; Laurence Vénat-Bouvet; Capucine Delnatte; Isabelle Mortemousque; Henry T. Lynch; Carrie L. Snyder

doi:10.1371/journal.pgen.1003173

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Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

Journal article

Open access

Peer reviewed

Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

Mia M. Gaudet, Karoline B. Kuchenbaecker, Joseph Vijai, Robert J. Klein, Tomas Kirchhoff, Lesley McGuffog, Daniel Barrowdale, Alison M. Dunning, Andrew Lee, Joe Dennis, …

PLoS genetics, Vol.9(3), e1003173

2013

DOI: https://doi.org/10.1371/journal.pgen.1003173

PMCID: PMC3609647

PMID: 23544012

Abstract

Ecology, Evolution, Behavior and Systematics

Molecular Biology

Genetics

Genetics(clinical)

Cancer Research

Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. DNA samples from 3,881 breast cancer affected and 4,330 unaffected BRCA2 mutation carriers from 47 studies belonging to the Consortium of Investigators of Modifiers of BRCA1/2 were genotyped and available for analysis. We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80-0.90, P = 3.9×10-8). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. This report identifies the first breast cancer risk locus specific to a BRCA2 mutation background. This comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers. This panel may have clinical utility for women with BRCA2 mutations weighing options for medical prevention of breast cancer.

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Title: Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk
Creators: Mia M. Gaudet (Author) - American Cancer Society
Karoline B. Kuchenbaecker (Author) - University of Cambridge
Joseph Vijai (Author) - Memorial Sloan-Kettering Cancer Center
Robert J. Klein (Author) - Memorial Sloan-Kettering Cancer Center
Tomas Kirchhoff (Author) - New York University
Lesley McGuffog (Author) - University of Cambridge
Daniel Barrowdale (Author) - University of Cambridge
Alison M. Dunning (Author) - University of Cambridge
Andrew Lee (Author) - University of Cambridge
Joe Dennis (Author) - University of Cambridge
Sue Healey (Author) - Queensland Institute of Medical Research
Ed Dicks (Author) - University of Cambridge
Penny Soucy (Author) - Université Laval
Olga M. Sinilnikova (Author) - Hospices Civils de Lyon-Centre Léon Bérard;UMR 5641 CNRS
Vernon S. Pankratz (Author) - Mayo Clinic Rochester, MN
Xianshu Wang (Author) - Mayo Clinic Rochester, MN
Ronald C. Eldridge (Author) - Emory University
Daniel C. Tessier (Author) - McGill University
Daniel Vincent (Author) - McGill University
Francois Bacot (Author) - McGill University
Frans B.L. Hogervorst (Author) - Netherlands Cancer Institute
Susan Peock (Author) - University of Cambridge;Coordinating Centre
Dominique Stoppa-Lyonnet (Author) - Institut Curie;Université Paris Cité;National Cancer Genetics Network
Florence Coulet (Author) - Sorbonne Université;National Cancer Genetics Network
Chrystelle Colas (Author) - Sorbonne Université;National Cancer Genetics Network
Florent Soubrier (Author) - Sorbonne Université;National Cancer Genetics Network
Paolo Peterlongo (Author) - IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano;FIRC Institute of Molecular Oncology
Rita K. Schmutzler (Author) - University of Cologne
Katherine L. Nathanson (Author) - University of Pennsylvania
Marion Piedmonte (Author) - Roswell Park Cancer Institute
Christian F. Singer (Author) - Medical University of Vienna
Mads Thomassen (Author) - University of Southern Denmark
Johanna Sokolowska (Author) - CHU de Nancy;National Cancer Genetics Network
Myriam Bronner (Author) - CHU de Nancy;National Cancer Genetics Network
Thomas V.O. Hansen (Author) - University of Copenhagen
Susan L. Neuhausen (Author) - City of Hope National Med Center
Ignacio Blanco (Author) - Institute Catala Oncologia
Mark H. Greene (Author) - National Institutes of Health
Judith Garber (Author) - Dana-Farber Cancer Institute
Jeffrey N. Weitzel (Author) - City of Hope National Med Center
Irene L. Andrulis (Author) - Mount Sinai Hospital;University of Toronto
David E. Goldgar (Author) - University of Utah
Emma D'Andrea (Author) - University of Padua;IRCCS Istituto Oncologico Veneto - Padova
Trinidad Caldes (Author) - Complutense University
Heli Nevanlinna (Author) - University of Helsinki
Ana Osorio (Author) - Instituto de Salud Carlos III
Elizabeth J. van Rensburg (Author) - University of Pretoria
Adalgeir Arason (Author) - Landspitali University Hospital;University of Iceland
Gad Rennert (Author) - Clalit Health Services
Ans M.W. van den Ouweland (Author) - Erasmus University Rotterdam;Netherlands Cancer Institute
Annemarie H. van der Hout (Author) - University of Groningen;Netherlands Cancer Institute
Carolien M. Kets (Author) - Radboud University Nijmegen;Netherlands Cancer Institute
Cora M. Aalfs (Author) - Amsterdam UMC - University of Amsterdam;Netherlands Cancer Institute
Juul T. Wijnen (Author) - Leiden University;Netherlands Cancer Institute
Margreet G.E.M. Ausems (Author) - Utrecht University;Netherlands Cancer Institute
Debra Frost (Author) - University of Cambridge;Coordinating Centre
Steve Ellis (Author) - University of Cambridge;Coordinating Centre
Elena Fineberg (Author) - University of Cambridge;Coordinating Centre
Radka Platte (Author) - University of Cambridge;Coordinating Centre
D. Gareth Evans (Author) - University of Cambridge;Manchester Regional Genetics Service
Chris Jacobs (Author) - University of Cambridge;Guy's and St Thomas' NHS Foundation Trust;King's College London
Julian Adlard (Author) - University of Cambridge;Yorkshire Regional Genetics Service
Marc Tischkowitz (Author) - University of Cambridge;East Anglian Regional Genetics Service
Mary E. Porteous (Author) - Western General Hospital
Francesca Damiola (Author) - UMR 5641 CNRS;National Cancer Genetics Network;Hospices Civils de Lyon-Centre Léon Bérard;Institut Curie
Lisa Golmard (Author) - Institut Curie
Laure Barjhoux (Author) - UMR 5641 CNRS;National Cancer Genetics Network;Hospices Civils de Lyon-Centre Léon Bérard;Institut Curie
Michel Longy (Author) - National Cancer Genetics Network;Université de Bordeaux;Centre Georges-François Leclerc
Muriel Belotti (Author) - Institut Curie;National Cancer Genetics Network
Sandra Fert Ferrer (Author) - National Cancer Genetics Network;Hôtel Dieu Centre Hospitalier
Sylvie Mazoyer (Author) - UMR 5641 CNRS;National Cancer Genetics Network;Hospices Civils de Lyon-Centre Léon Bérard;Institut Curie
Amanda B. Spurdle (Author) - Queensland Institute of Medical Research
Siranoush Manoukian (Author) - IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano
Monica Barile (Author) - IRCCS Istituto Europeo di Oncologia - Milano
Maurizio Genuardi (Author) - University of Florence
Norbert Arnold (Author) - Kiel University
Alfons Meindl (Author) - Technical University of Munich
Christian Sutter (Author) - Heidelberg University
Barbara Wappenschmidt (Author) - University of Cologne
Susan M. Domchek (Author) - University of Pennsylvania
Georg Pfeiler (Author) - Medical University of Vienna
Eitan Friedman (Author) - Sheba Medical Center at Tel Hashomer
Uffe Birk Jensen (Author) - Aarhus University
Mark Robson (Author) - Memorial Sloan-Kettering Cancer Center
Sohela Shah (Author) - Memorial Sloan-Kettering Cancer Center
Conxi Lazaro (Author) - Institute Catala Oncologia
Phuong L. Mai (Author) - National Institutes of Health
Javier Benitez (Author) - Instituto de Salud Carlos III
Melissa C. Southey (Author) - University of Melbourne
M. K. Schmidt (Author) - Netherlands Cancer Institute;Antoni van Leeuwenhoek Hospital
Peter A. Fasching (Author) - Friedrich-Alexander University Erlangen-Nürnberg;University of California at Los Angeles
Julian Peto (Author) - London School of Hygiene and Tropical Medicine
Manjeet K. Humphreys (Author) - University of Cambridge
Qin Wang (Author) - University of Cambridge
Kyriaki Michailidou (Author) - University of Cambridge
Elinor J. Sawyer (Author) - Guy's and St Thomas' NHS Foundation Trust
Barbara Burwinkel (Author) - Heidelberg University ;German Cancer Research Center
Pascal Guénel (Author) - National Institutes of Health, Bethesda;ComUE Paris-Saclay
Stig E. Bojesen (Author) - University of Copenhagen
Roger L. Milne (Author) - Instituto de Salud Carlos III
Hermann Brenner (Author) - German Cancer Research Center
Magdalena Lochmann (Author) - Technical University of Munich
Hiltrud Brauch (Author) - Robert Bosch Krankenhaus Stuttgart;University of Tübingen
Yon Dschun Ko (Author) - Johanniter Krankenhaus
Christian Baisch (Author) - Johanniter Krankenhaus
Hand Peter Fischer (Author) - University of Bonn
Thomas Bruening (Author) - German Cancer Research Center;Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
Beate Pesch (Author) - German Cancer Research Center;Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
Sylvia Rabstein (Author) - German Cancer Research Center;Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
Anne Spickenheuer (Author) - German Cancer Research Center;Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA)
Kristiina Aittomäki (Author) - University of Helsinki
Thilo Dörk (Author) - Hannover Medical School
Sara Margolin (Author) - Karolinska Institutet
Arto Mannermaa (Author) - University of Eastern Finland
Diether Lambrechts (Author) - Flanders Institute for Biotechnology;KU Leuven
Jenny Chang-Claude (Author) - German Cancer Research Center
Paolo Radice (Author) - IRCCS Fondazione Istituto Nazionale per lo studio e la cura dei tumori - Milano;FIRC Institute of Molecular Oncology
Graham G. Giles (Author) - Cancer Council Victoria;University of Melbourne
Christopher A. Haiman (Author) - University of Southern California
Robert Winqvist (Author) - University of Oulu
Peter Devillee (Author) - Leiden University
Montserrat García-Closas (Author) - Institute of Cancer Research
Nils Schoof (Author) - Karolinska Institutet
M. J. Hooning (Author) - Netherlands Cancer Institute;Erasmus University Rotterdam
Angela Cox (Author) - University of Sheffield
Paul D.P. Pharoah (Author) - University of Cambridge
Anna Jakubowska (Author) - Pomeranian Medical University in Szczecin
Nick Orr (Author) - Institute of Cancer Research
Anna González-Neira (Author) - Instituto de Salud Carlos III
Guillermo Pita (Author) - Instituto de Salud Carlos III
M. Rosario Alonso (Author) - Instituto de Salud Carlos III
Per Hall (Author) - Institute of Cancer Research
Fergus J. Couch (Author) - Mayo Clinic Rochester, MN
Jacques Simard (Author) - Université Laval
David Altshuler (Author) - Harvard University;Broad Institute
Douglas F. Easton (Author) - University of Cambridge
Georgia Chenevix-Trench (Author) - Queensland Institute of Medical Research
Antonis C. Antoniou (Author) - University of Cambridge
Kenneth Offit (Author) - Memorial Sloan-Kettering Cancer Center
M. A. Rookus (Author) - Netherlands Cancer Institute
F. E. van Leeuwen (Author) - Netherlands Cancer Institute
S. Verhoef (Author) - Netherlands Cancer Institute
J. L. de Lange (Author) - Netherlands Cancer Institute
J. M. Collée (Author) - Netherlands Cancer Institute;Erasmus University Rotterdam
C. Seynaeve (Author) - Netherlands Cancer Institute;Erasmus University Rotterdam
C. H.M. van Deurzen (Author) - Netherlands Cancer Institute;Erasmus University Rotterdam
C. J. van Asperen (Author) - Netherlands Cancer Institute;Leiden University
R. A. Tollenaar (Author) - Netherlands Cancer Institute;Leiden University
P. Devilee (Author) - Netherlands Cancer Institute;Leiden University
T. C.T.E.F. van Cronenburg (Author) - Netherlands Cancer Institute;Leiden University
A. R. Mensenkamp (Author) - Netherlands Cancer Institute;Radboud University Nijmegen
R. B. van der Luijt (Author) - Netherlands Cancer Institute;Utrecht University
T. A.M. van Os (Author) - Netherlands Cancer Institute;Amsterdam UMC - University of Amsterdam
J. J.P. Gille (Author) - Netherlands Cancer Institute;VU Medical Center
Q. Waisfisz (Author) - Netherlands Cancer Institute;VU Medical Center
H. E.J. Meijers-Heijboer (Author) - Netherlands Cancer Institute;VU Medical Center
E. B. Gómez-Garcia (Author) - Netherlands Cancer Institute;Maastricht University
M. J. Blok (Author) - Netherlands Cancer Institute;Maastricht University
J. C. Oosterwijk (Author) - Netherlands Cancer Institute;University of Groningen
M. J. Mourits (Author) - Netherlands Cancer Institute;University of Groningen
G. H. de Bock (Author) - Netherlands Cancer Institute;University of Groningen
H. F. Vasen (Author) - Netherlands Cancer Institute;Foundation for the Detection of Hereditary Tumours
Zosia Miedzybrodzka (Author) - University of Cambridge;North of Scotland Regional Genetics Service
Helen Gregory (Author) - University of Cambridge;North of Scotland Regional Genetics Service
Patrick Morrison (Author) - University of Cambridge;Northern Ireland Regional Genetics Service
Lisa Jeffers (Author) - University of Cambridge;Northern Ireland Regional Genetics Service
Trevor Cole (Author) - University of Cambridge;West Midlands Regional Clinical Genetics Service
Kai ren Ong (Author) - University of Cambridge;West Midlands Regional Clinical Genetics Service
Jonathan Hoffman (Author) - University of Cambridge;West Midlands Regional Clinical Genetics Service
Alan Donaldson (Author) - University of Cambridge
Margaret James (Author) - University of Cambridge
Joan Paterson (Author) - University of Cambridge;East Anglian Regional Genetics Service
Amy Taylor (Author) - University of Cambridge;East Anglian Regional Genetics Service
Alexandra Murray (Author) - University of Cambridge;Medical Genetics Services for Wales
Mark T. Rogers (Author) - University of Cambridge;Medical Genetics Services for Wales
Emma McCann (Author) - University of Cambridge;Medical Genetics Services for Wales
M. John Kennedy (Author) - University of Cambridge;Trinity College Dublin
David Barton (Author) - University of Cambridge;Trinity College Dublin
Mary Porteous (Author) - University of Cambridge
Sarah Drummond (Author) - University of Cambridge
Carole Brewer (Author) - University of Cambridge;Peninsula Clinical Genetics Service
Emma Kivuva (Author) - University of Cambridge;Peninsula Clinical Genetics Service
Anne Searle (Author) - University of Cambridge;Peninsula Clinical Genetics Service
Selina Goodman (Author) - University of Cambridge;Peninsula Clinical Genetics Service
Kathryn Hill (Author) - University of Cambridge;Peninsula Clinical Genetics Service
Rosemarie Davidson (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Victoria Murday (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Nicola Bradshaw (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Lesley Snadden (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Mark Longmuir (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Catherine Watt (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Sarah Gibson (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Eshika Haque (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Ed Tobias (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Alexis Duncan (Author) - University of Cambridge;West of Scotland Regional Genetics Service
Louise Izatt (Author) - University of Cambridge;King's College London
Caroline Langman (Author) - University of Cambridge;King's College London
Angela Brady (Author) - University of Cambridge
Huw Dorkins (Author) - University of Cambridge
Athalie Melville (Author) - University of Cambridge
Kashmir Randhawa (Author) - University of Cambridge
Julian Barwell (Author) - University of Cambridge;Leicestershire Clinical Genetics Service
Gemma Serra-Feliu (Author) - University of Cambridge;Yorkshire Regional Genetics Service
Ian Ellis (Author) - University of Cambridge;Cheshire and Merseyside Clinical Genetics Service
Catherine Houghton (Author) - University of Cambridge;Cheshire and Merseyside Clinical Genetics Service
Fiona Lalloo (Author) - University of Cambridge;Manchester Regional Genetics Service
Jane Taylor (Author) - University of Cambridge;Manchester Regional Genetics Service
Lucy Side (Author) - University of Cambridge
Alison Male (Author) - University of Cambridge
Cheryl Berlin (Author) - University of Cambridge
Jacqueline Eason (Author) - University of Cambridge;Nottingham University Hospitals NHS Trust
Fiona Douglas (Author) - University of Cambridge;Northern Clinical Genetics Service
Oonagh Claber (Author) - University of Cambridge;Northern Clinical Genetics Service
Rebecca Collier (Author) - University of Cambridge;Nottingham University Hospitals NHS Trust
Irene Jobson (Author) - University of Cambridge;Northern Clinical Genetics Service
Lisa Walker (Author) - University of Cambridge;Oxford Regional Genetics Service
Diane McLeod (Author) - University of Cambridge;Oxford Regional Genetics Service
Sarah Durell (Author) - University of Cambridge;Oxford Regional Genetics Service
Barbara Stayner (Author) - University of Cambridge;Oxford Regional Genetics Service
Rosalind A. Eeles (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Susan Shanley (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Nazneen Rahman (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Richard Houlston (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Elizabeth Bancroft (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Elizabeth Page (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Audrey Ardern-Jones (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Kelly Kohut (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Jennifer Wiggins (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Elena Castro (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Emma Killick (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Sue Martin (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Gillian Rea (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Anjana Kulkarni (Author) - University of Cambridge;Royal Marsden NHS Foundation Trust
Jackie Cook (Author) - University of Cambridge;North Trent Clinical Genetics Service
Oliver Quarrell (Author) - University of Cambridge;North Trent Clinical Genetics Service
Cathryn Bardsley (Author) - University of Cambridge;North Trent Clinical Genetics Service
Shirley Hodgson (Author) - University of Cambridge
Sheila Goff (Author) - University of Cambridge
Glen Brice (Author) - University of Cambridge
Lizzie Winchester (Author) - University of Cambridge
Charlotte Eddy (Author) - University of Cambridge
Vishakha Tripathi (Author) - University of Cambridge
Virginia Attard (Author) - University of Cambridge
Anna Lehmann (Author) - University of Cambridge
Diana Eccles (Author) - University of Cambridge;University Hospital Southampton NHS Foundation Trust
Anneke Lucassen (Author) - University of Cambridge;University Hospital Southampton NHS Foundation Trust
Gillian Crawford (Author) - University of Cambridge;University Hospital Southampton NHS Foundation Trust
Donna McBride (Author) - University of Cambridge;University Hospital Southampton NHS Foundation Trust
Sarah Smalley (Author) - University of Cambridge;University Hospital Southampton NHS Foundation Trust
Olga Sinilnikova (Author) - National Cancer Genetics Network;Hospices Civils de Lyon-Centre Léon Bérard;Institut Curie
Carole Verny-Pierre (Author) - National Cancer Genetics Network;Hospices Civils de Lyon-Centre Léon Bérard;Institut Curie
Sophie Giraud (Author) - National Cancer Genetics Network;Hospices Civils de Lyon-Centre Léon Bérard;Institut Curie
Mélanie Léone (Author) - National Cancer Genetics Network;Hospices Civils de Lyon-Centre Léon Bérard;Institut Curie
Marion Gauthier-Villars (Author) - National Cancer Genetics Network;Institut Curie
Bruno Buecher (Author) - National Cancer Genetics Network;Institut Curie
Claude Houdayer (Author) - National Cancer Genetics Network;Institut Curie
Virginie Moncoutier (Author) - National Cancer Genetics Network;Institut Curie
Carole Tirapo (Author) - National Cancer Genetics Network;Institut Curie
Antoine de Pauw (Author) - National Cancer Genetics Network;Institut Curie
Brigitte Bressac-de-Paillerets (Author) - National Cancer Genetics Network;Institut Gustave Roussy
Olivier Caron (Author) - National Cancer Genetics Network;Institut Gustave Roussy
Yves Jean Bignon (Author) - National Cancer Genetics Network;Centre Jean Perrin
Nancy Uhrhammer (Author) - National Cancer Genetics Network;Centre Jean Perrin
Christine Lasset (Author) - National Cancer Genetics Network;Centre Léon Bérard
Valérie Bonadona (Author) - National Cancer Genetics Network;Centre Léon Bérard
Sandrine Handallou (Author) - National Cancer Genetics Network;Centre Léon Bérard
Agnés Hardouin (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Pascaline Berthet (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Hagay Sobol (Author) - National Cancer Genetics Network;Institut Paoli Calmettes
Violaine Bourdon (Author) - National Cancer Genetics Network;Institut Paoli Calmettes
Tetsuro Noguchi (Author) - National Cancer Genetics Network;Institut Paoli Calmettes
Audrey Remenieras (Author) - National Cancer Genetics Network;Institut Paoli Calmettes
Isabelle Coupier (Author) - National Cancer Genetics Network;Institut Paoli Calmettes;Hôpital Arnaud de Villeneuve
Pascal Pujol (Author) - National Cancer Genetics Network;Hôpital Arnaud de Villeneuve
Jean Philippe Peyrat (Author) - National Cancer Genetics Network;Centre Oscar Lambret
Joëlle Fournier (Author) - National Cancer Genetics Network;Centre Oscar Lambret
Françoise Révillion (Author) - National Cancer Genetics Network;Centre Oscar Lambret
Philippe Vennin (Author) - National Cancer Genetics Network;Centre Oscar Lambret
Claude Adenis (Author) - National Cancer Genetics Network;Centre Oscar Lambret
Etienne Rouleau (Author) - National Cancer Genetics Network;Institut Curie
Rosette Lidereau (Author) - National Cancer Genetics Network;Institut Curie
Liliane Demange (Author) - National Cancer Genetics Network;Institut Curie
Catherine Nogues (Author) - National Cancer Genetics Network;Institut Curie
Danièle Muller (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Jean Pierre Fricker (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Emmanuelle Barouk-Simonet (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Françoise Bonnet (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Virginie Bubien (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Nicolas Sevenet (Author) - National Cancer Genetics Network;Centre Georges-François Leclerc
Christine Toulas (Author) - National Cancer Genetics Network;Institut Claudius Regaud
Rosine Guimbaud (Author) - National Cancer Genetics Network;Institut Claudius Regaud
Laurence Gladieff (Author) - National Cancer Genetics Network;Institut Claudius Regaud
Viviane Feillel (Author) - National Cancer Genetics Network;Institut Claudius Regaud
Hélène Dreyfus (Author) - National Cancer Genetics Network;Universite Joseph Fourier
Christine Rebischung (Author) - National Cancer Genetics Network;Universite Joseph Fourier
Magalie Peysselon (Author) - National Cancer Genetics Network;Universite Joseph Fourier
Fanny Coron (Author) - National Cancer Genetics Network;Université de Bourgogne
Laurence Faivre (Author) - National Cancer Genetics Network;Université de Bourgogne
Fabienne Prieur (Author) - National Cancer Genetics Network;CHU de Saint-Étienne
Marine Lebrun (Author) - National Cancer Genetics Network;CHU de Saint-Étienne
Caroline Kientz (Author) - National Cancer Genetics Network;CHU de Saint-Étienne
Marc Frénay (Author) - National Cancer Genetics Network;Centre Antoine Lacassagne
Laurence Vénat-Bouvet (Author) - National Cancer Genetics Network;CHU de Limoges
Capucine Delnatte (Author) - National Cancer Genetics Network;Centre Hospitalier Universitaire
Isabelle Mortemousque (Author) - National Cancer Genetics Network;Hôpital Bretonneau
Henry T. Lynch (Author) - Department of Preventive Medicine
Carrie L. Snyder (Author) - National Cancer Genetics Network;Creighton University
Additional links: Valle, S.
Publication Details: PLoS genetics, Vol.9(3), e1003173
Series: 9
Identifiers: 991005930540802656
Academic Unit: Prev. Medicine & Public Health
Language: English
Resource Type: Journal article