Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

D.B. Johnson; M.B. Atkins; C. Hennessy; T. Wise-Draper; H. Heilman; J. Awosika; Z. Bakouny; C. Labaki; R.M. Saliby; C. Hwang; S.R.K. Singh; N. Balanchivadze; C.R. Friese; L.A. Fecher; J.J. Yoon; B. Hayes-Lattin; M.A. Bilen; C.A. Castellano; G.H. Lyman; L. Tachiki; S.A. Shah; M.J. Glover; D.B. Flora; E. Wulff-Burchfield; A. Kasi; S.H. Abbasi; D. Farmakiotis; K. Viera; E.J. Klein; L.B. Weissman; C. Jani; M. Puc; C.C. Fahey; D.Y. Reuben; S. Mishra; A. Beeghly-Fadiel; B. French; J.L. Warner; S.A. Reid; A.J. Brown; A. Cheng; S. Croessmann; E.J. Davis; K.T. Enriquez; E.A. Gillaspie; D. Hausrath; X. Li; D.A. Slosky; C.C. Solorzano; M.D. Tucker; K. Vega-Luna; L.L. Wang; S.A. Ahmad; P. Grover; S. Gulati; J. Kharofa; T. Latif; M. Marcum; D.P.S. Sohal; O. Zamulko; T.K. Choueiri; J.M. Connors; G.D. Demetri; N. Duma; D.A. Freeman; A. Giordano; A.K. Morgans; A. Nohria; A.L. Schmidt; E.M. Van Allen; W. Xu; R.L. Zon; S.M. Gadgeel; S. Tejwani; A. Boldt; A.M. Cohen; S. McWeeney; E.R. Nemecek; S.P. Williamson; D. Ravindranathan; J.J. Graber; P. Grivas; J.E. Hawley; E.T. Loggers; R.C. Lynch; E.S. Nakasone; M.T. Schweizer; S. Vinayak; M.J. Wagner; A. Yeh; E.C. Cabebe; A. Jha; A.R. Khaki; L. Schapira; J.T.-Y. Wu; G. Kloecker; B.B. Logan; C. Mandapakala; C.D. Rock; P. Arvanitis; P.C. Egan; H. Khan; A.J. Olszewski; K. Vieira; L.B. Weissmann; P.S. Bhatt; M.G. Mariano; C.C. Thomson; T.M. Carducci; K.J. Goldsmith; S. Van Loon; M. Alexander; S. Matar; S. Mushtaq; K.E. Stockerl-Goldstein; O. Butt; M.A. Fiala; J.P. Henderson; R.S. Monahan; A.Y. Zhou; P.E. Lammers; S.G. Revankar; S.A. Del Prete; M.H. Bar; A.P. Gulati; K.M.S. Lo; S.J. Rose; J. Stratton; P.L. Weinstein; S. Gupta; N.A. Pennell; M.S. Ahluwalia; S.J. Dawsey; C.A. Lemmon; A. Nizam; N. Sharifi; C. Hoppenot; A. Li; S. Halabi; H. Dzimitrowicz; T. Zhang; S. Goyal; M.-P. Huynh-Le; P.P. Yu; J.M. Clement; A. Daher; M.E. Dailey; R. Elias; A. Jayaraj; E. Hsu; A.G. Menendez; O.K. Serrano; M.K. Accordino; D. Bhutani; D. Hershman; M.A. Ingham; G.K. Schwartz; E.H. Bernicker; J.F. Deeken; D. Shafer; E. Ruíz-García; A. Ramirez; D. Vilar-Compte; M.A. Lewis; T.D. Rhodes; D.M. Gill; C.A. Low; S.H. Mashru; A.-H. Mansoor; G.C. Lewis; S.J. Smith; H.A. Zaren; G. Nagaraj; M. Akhtari; D.R. Castillo; E. Lau; M.E. Reeves; S. Berg; N. Knox; T.E. O’Connor; E.B. Durbin; A.A. Kulkarni; H.H. Nelson; Z. Sachs; R.P. Rosovsky; K.L. Reynolds; A. Bardia; G. Boland; J.F. Gainor; L. Zubiri; T.R. Halfdanarson; T.S. Bekaii-Saab; A. Desai; I.B. Riaz; S. Shah; K.E. Smith; C. Williams; N. Bouganim; A. Elkrief; J. Panasci; D.C. Vinh; G.J. Riely; R. Belenkaya; J. Philip; B. Faller; R.R. McKay; A. Ajmera; S.S. Brouha; S. Choi; A. Hsiao; S. Kligerman; T.K. Nonato; E.G.R.S. Blau; S.R. Jhawar; D. Addison; J.L. Chen; M.E. Gatti-Mays; V. Karivedu; J.D. Palmer; D.G. Stover; S. Wall; N.O. Williams; M. Joshi; H.V. Polimera; L.D. Pomerantz; M.A. Rovito; E.A. Griffiths; P.G. Advani; I. Puzanov; S.K. Jabbour; C.F. Misdary; M.R. Shah; G. Batist; E. Cook; M.S. Dutra; C. Ferrario; W.H. Miller; B. Bashir; C. McNair; S.Z. Mahmood; V. Mico; A.V. Rivera; N.C. Edwin; M. Smits; D.B. Doroshow; M.D. Galsky; M. Wotman; A. Fazio; J.C. Fu; K.E. Huber; M.H. Sueyoshi; V.S. Koshkin; H.T. Borno; D.H. Kwon; E.J. Small; S. Zhang; S.M. Rubinstein; W.A. Wood; T.M. Andermann; C. Jensen; D.W. Bowles; C.L. Geiger; L.E. Feldman; K.F. Hoskins; G. Gantt; L.C. Liu; M. Khan; R.H. Nguyen; M. Pasquinelli; C. Schwartz; N.K. Venepalli; B.H. Mavromatis; R.R. Bijjula; Q.U. Zaman; D.M. Aboulafiam; B.A. Schroeder; U. Topaloglu; S.I. Alimohamed; J.K. Moore; P. Peddi; L.R. Rosen; B.B. McCollough; N. Hafez; R. Herbst; P. LoRusso; M.B. Lustberg; T. Masters; C. Stratton

doi:10.1186/s12885-023-10708-6

Back

Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

Journal article

Open access

Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma

D.B. Johnson, M.B. Atkins, C. Hennessy, T. Wise-Draper, H. Heilman, J. Awosika, Z. Bakouny, C. Labaki, R.M. Saliby, C. Hwang, …

BMC Cancer, Vol.23(1)

2023

DOI: https://doi.org/10.1186/s12885-023-10708-6

Abstract

Cancer

COVID-19

Immune therapy

Melanoma

Targeted therapy

COVID-19

Humans

Immunotherapy

Melanoma

Multiple Organ Failure

adult

aged

Article

artificial ventilation

cancer model

cancer patient

cancer survival

cancer survivor

cancer therapy

clinical assessment

cohort analysis

coronavirus disease 2019

female

hospital patient

hospitalization

human

immunosuppressive treatment

immunotherapy

major clinical study

male

melanoma

molecularly targeted therapy

outcome assessment

oxygen consumption

oxygenation

polymerase chain reaction

retrospective study

sun exposure

survival rate

United States

young adult

complication

melanoma

multiple organ failure

Introduction: COVID-19 particularly impacted patients with co-morbid conditions, including cancer. Patients with melanoma have not been specifically studied in large numbers. Here, we sought to identify factors that associated with COVID-19 severity among patients with melanoma, particularly assessing outcomes of patients on active targeted or immune therapy. Methods: Using the COVID-19 and Cancer Consortium (CCC19) registry, we identified 307 patients with melanoma diagnosed with COVID-19. We used multivariable models to assess demographic, cancer-related, and treatment-related factors associated with COVID-19 severity on a 6-level ordinal severity scale. We assessed whether treatment was associated with increased cardiac or pulmonary dysfunction among hospitalized patients and assessed mortality among patients with a history of melanoma compared with other cancer survivors. Results: Of 307 patients, 52 received immunotherapy (17%), and 32 targeted therapy (10%) in the previous 3 months. Using multivariable analyses, these treatments were not associated with COVID-19 severity (immunotherapy OR 0.51, 95% CI 0.19 – 1.39; targeted therapy OR 1.89, 95% CI 0.64 – 5.55). Among hospitalized patients, no signals of increased cardiac or pulmonary organ dysfunction, as measured by troponin, brain natriuretic peptide, and oxygenation were noted. Patients with a history of melanoma had similar 90-day mortality compared with other cancer survivors (OR 1.21, 95% CI 0.62 – 2.35). Conclusions: Melanoma therapies did not appear to be associated with increased severity of COVID-19 or worsening organ dysfunction. Patients with history of melanoma had similar 90-day survival following COVID-19 compared with other cancer survivors. © 2023, The Author(s).

Files and links (2)

url

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85150805325&doi=10.1186%2fs12885-023-10708-6&partnerID=40&md5=98066f17c3e7a71c25fffe5847778921View

url

https://doi.org/10.1186/s12885-023-10708-6View

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: Impact of COVID-19 in patients on active melanoma therapy and with history of melanoma
Creators: D.B. Johnson - Vanderbilt University Medical Center
M.B. Atkins - Georgetown University
C. Hennessy - Vanderbilt University Medical Center
T. Wise-Draper - University of Cincinnati
H. Heilman - University of Cincinnati
J. Awosika - University of Cincinnati
Z. Bakouny - Dana-Farber Cancer Institute
C. Labaki - Dana-Farber Cancer Institute
R.M. Saliby - Dana-Farber Cancer Institute
C. Hwang - Henry Ford Hospital
S.R.K. Singh
N. Balanchivadze - Henry Ford Hospital
C.R. Friese - University of Michigan–Ann Arbor
L.A. Fecher - University of Michigan–Ann Arbor
J.J. Yoon - University of Michigan–Ann Arbor
B. Hayes-Lattin - Oregon Health & Science University
M.A. Bilen - Emory University
C.A. Castellano - Emory University
G.H. Lyman - Fred Hutch Cancer Center
L. Tachiki - Fred Hutch Cancer Center
S.A. Shah - Stanford University
M.J. Glover - Stanford University
D.B. Flora - St. Elizabeth Healthcare
E. Wulff-Burchfield - The University of Kansas Cancer Center
A. Kasi - The University of Kansas Cancer Center
S.H. Abbasi - The University of Kansas Cancer Center
D. Farmakiotis - Brown University
K. Viera - Brown University
E.J. Klein - Brown University
L.B. Weissman - Mount Auburn Hospital
C. Jani - Mount Auburn Hospital
M. Puc - Virtua Health
C.C. Fahey - Vanderbilt University Medical Center
D.Y. Reuben - Medical University of South Carolina
S. Mishra - Vanderbilt University Medical Center
A. Beeghly-Fadiel - Vanderbilt University Medical Center
B. French - Vanderbilt University Medical Center
J.L. Warner - Brown University
S.A. Reid
A.J. Brown
A. Cheng
S. Croessmann
E.J. Davis - Brown University
K.T. Enriquez
E.A. Gillaspie - Vanderbilt University Medical Center
D. Hausrath - MUSC Hollings Cancer Center
X. Li - Mount Auburn Hospital
D.A. Slosky
C.C. Solorzano
M.D. Tucker
K. Vega-Luna
L.L. Wang
S.A. Ahmad
P. Grover
S. Gulati
J. Kharofa
T. Latif
M. Marcum
D.P.S. Sohal
O. Zamulko
T.K. Choueiri
J.M. Connors
G.D. Demetri
N. Duma
D.A. Freeman
A. Giordano
A.K. Morgans
A. Nohria
A.L. Schmidt
E.M. Van Allen
W. Xu
R.L. Zon
S.M. Gadgeel
S. Tejwani
A. Boldt
A.M. Cohen
S. McWeeney
E.R. Nemecek
S.P. Williamson
D. Ravindranathan
J.J. Graber
P. Grivas
J.E. Hawley
E.T. Loggers
R.C. Lynch
E.S. Nakasone
M.T. Schweizer
S. Vinayak
M.J. Wagner - Stanford University
A. Yeh
E.C. Cabebe
A. Jha
A.R. Khaki
L. Schapira
J.T.-Y. Wu
G. Kloecker
B.B. Logan
C. Mandapakala
C.D. Rock
P. Arvanitis
P.C. Egan
H. Khan
A.J. Olszewski
K. Vieira - Brown University
L.B. Weissmann - Mount Auburn Hospital
P.S. Bhatt
M.G. Mariano
C.C. Thomson
T.M. Carducci
K.J. Goldsmith
S. Van Loon
M. Alexander
S. Matar
S. Mushtaq
K.E. Stockerl-Goldstein
O. Butt
M.A. Fiala
J.P. Henderson
R.S. Monahan
A.Y. Zhou
P.E. Lammers
S.G. Revankar
S.A. Del Prete
M.H. Bar
A.P. Gulati
K.M.S. Lo - St. Elizabeth Healthcare
S.J. Rose
J. Stratton
P.L. Weinstein
S. Gupta
N.A. Pennell
M.S. Ahluwalia
S.J. Dawsey
C.A. Lemmon - University of Michigan–Ann Arbor
A. Nizam
N. Sharifi
C. Hoppenot
A. Li - Mount Auburn Hospital
S. Halabi
H. Dzimitrowicz - University of Cincinnati
T. Zhang
S. Goyal
M.-P. Huynh-Le
P.P. Yu
J.M. Clement
A. Daher
M.E. Dailey
R. Elias
A. Jayaraj
E. Hsu
A.G. Menendez
O.K. Serrano
M.K. Accordino
D. Bhutani
D. Hershman
M.A. Ingham - Virtua Health
G.K. Schwartz
E.H. Bernicker
J.F. Deeken
D. Shafer
E. Ruíz-García
A. Ramirez
D. Vilar-Compte
M.A. Lewis
T.D. Rhodes
D.M. Gill
C.A. Low
S.H. Mashru
A.-H. Mansoor
G.C. Lewis
S.J. Smith
H.A. Zaren
G. Nagaraj
M. Akhtari
D.R. Castillo
E. Lau
M.E. Reeves
S. Berg
N. Knox
T.E. O’Connor
E.B. Durbin
A.A. Kulkarni
H.H. Nelson
Z. Sachs
R.P. Rosovsky
K.L. Reynolds
A. Bardia
G. Boland
J.F. Gainor
L. Zubiri
T.R. Halfdanarson
T.S. Bekaii-Saab
A. Desai
I.B. Riaz
S. Shah - Stanford University
K.E. Smith
C. Williams
N. Bouganim
A. Elkrief
J. Panasci
D.C. Vinh
G.J. Riely
R. Belenkaya
J. Philip - Vanderbilt University Medical Center
B. Faller
R.R. McKay
A. Ajmera
S.S. Brouha
S. Choi
A. Hsiao
S. Kligerman
T.K. Nonato
E.G.R.S. Blau
S.R. Jhawar
D. Addison - MUSC Hollings Cancer Center
J.L. Chen
M.E. Gatti-Mays
V. Karivedu
V. Karivedu
J.D. Palmer
D.G. Stover
S. Wall
N.O. Williams
M. Joshi
H.V. Polimera
L.D. Pomerantz
M.A. Rovito
E.A. Griffiths - Brown University
P.G. Advani
I. Puzanov
S.K. Jabbour
C.F. Misdary
M.R. Shah - Stanford University
G. Batist
E. Cook - Vanderbilt University Medical Center
M.S. Dutra
C. Ferrario
W.H. Miller
B. Bashir
C. McNair - University of Michigan–Ann Arbor
S.Z. Mahmood
V. Mico
A.V. Rivera
N.C. Edwin
M. Smits
D.B. Doroshow
M.D. Galsky
M. Wotman - Stanford University
A. Fazio
J.C. Fu
K.E. Huber
M.H. Sueyoshi
V.S. Koshkin
H.T. Borno
D.H. Kwon
E.J. Small
S. Zhang
S.M. Rubinstein
W.A. Wood
T.M. Andermann
C. Jensen - University of Michigan–Ann Arbor
D.W. Bowles
C.L. Geiger
L.E. Feldman
K.F. Hoskins
G. Gantt
L.C. Liu - Vanderbilt University Medical Center
M. Khan
R.H. Nguyen
M. Pasquinelli
C. Schwartz
N.K. Venepalli
B.H. Mavromatis
R.R. Bijjula
Q.U. Zaman
D.M. Aboulafiam
B.A. Schroeder
U. Topaloglu - Stanford University
S.I. Alimohamed
J.K. Moore
P. Peddi
L.R. Rosen
B.B. McCollough
N. Hafez
R. Herbst
P. LoRusso
M.B. Lustberg
T. Masters
C. Stratton - Vanderbilt University Medical Center
Publication Details: BMC Cancer, Vol.23(1)
Publisher: BioMed Central Ltd
Identifiers: 991006160923002656
Language: English
Resource Type: Journal article