Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean Marie Galano; Emilie Mas; Anne Barden; Trevor A. Mori; Cinzia Signorini; Claudio De Felice; Aaron Barrett; Catherine Opere; Edith Pinot; Edzard Schwedhelm; Ralf Benndorf; Jérôme Roy; Jean Yves Le Guennec; Camille Oger; Thierry Durand

doi:10.1016/j.prostaglandins.2013.04.003

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Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Journal article

Peer reviewed

Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

Jean Marie Galano, Emilie Mas, Anne Barden, Trevor A. Mori, Cinzia Signorini, Claudio De Felice, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, …

Prostaglandins and Other Lipid Mediators, Vol.107, pp.95-102

107

2013

DOI: https://doi.org/10.1016/j.prostaglandins.2013.04.003

PMID: 23644158

Abstract

Biochemistry

Physiology

Pharmacology

Cell Biology

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

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Title: Isoprostanes and neuroprostanes
Creators: Jean Marie Galano (Author) - Institut des Biomolécules Max Mousseron
Emilie Mas (Author) - University of Western Australia
Anne Barden (Author) - University of Western Australia
Trevor A. Mori (Author) - University of Western Australia
Cinzia Signorini (Author) - University of Siena
Claudio De Felice (Author) - Azienda Ospedaliera Universitaria Senese
Aaron Barrett (Author) - Creighton University
Catherine Opere (Author) - Department of Pharmacy Sciences
Edith Pinot (Author) - Institut des Biomolécules Max Mousseron
Edzard Schwedhelm (Author) - University Medical Center Hamburg-Eppendorf
Ralf Benndorf (Author) - University of Würzburg
Jérôme Roy (Author) - Institut national de la santé et de la recherche médicale
Jean Yves Le Guennec (Author) - Institut national de la santé et de la recherche médicale
Camille Oger (Author) - Institut des Biomolécules Max Mousseron
Thierry Durand (Author) - Institut des Biomolécules Max Mousseron
Publication Details: Prostaglandins and Other Lipid Mediators, Vol.107, pp.95-102
Series: 107
Number of pages: 8
Identifiers: 991005929006702656
Academic Unit: Pharmacy Sciences
Language: English
Resource Type: Journal article

Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans

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