Author contributions: All authors had full access to all the data in the study; therefore, all take responsibility for the integrity of the data and the accuracy of the data analysis, including and especially any adverse effects. R. S. I. sered as the principal author. C. L. F. and N. D. contributed substantially to the study design, data analysis, and interpretation, and the writing of the manuscript. Financial/nonfinancial disclosures: The authors have reported to CHEST the following: R. S. I. and C. L. F. as co-developers of the Cough Quality of Life Questionnaire, report that they hold the copyright of this patient-reported outcome measure that is mentioned in this review. None declared (N. D.). ∗CHEST Expert Cough Panel Collaborators: Abd Moain Abu Dabrh, MBBCh, MS (Mayo Clinic, Jacksonville, FL); Kenneth W. Altman, MD, PhD (Geisinger Commonwealth School of Medicine, Danville, PA); Elie Azoulay, MD, PhD (University of Paris, Paris, France); Alan F. Barker, MD (Oregon Health & Science University, Portland, OR); Surinder S. Birring, MBChB, MD (Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London, United Kingdom); Donald C. Bolser, PhD, and Louis-Philippe Boulet, MD, FCCP (Institut universitaire de cardiologie et de pneumonlogie de Québec, Quebec, [IUCPQ], QC, Canada); Sidney S. Braman, MD, FCCP (Mount Sinai Hospital, New York, NY); Christopher Brightling, MBBS, PhD, FCCP (University of Leicester, Glenfield Hospital, Leicester, United Kingdom); Brendan Canning, PhD (Johns Hopkins Asthma and Allergy Center, Baltimore, MD); Anne B. Chang, MBBS, PhD, MPH (Royal Children's Hospital, Queensland, Australia); Terrie Cowley (The TMJ Association, Milwaukee, WI); Paul Davenport, PhD (Department of Physiological Sciences, University of Florida, Gainesville, FL); Ali A. El Solh, MD, MPH (University at Buffalo, State University of New York, Buffalo, NY); Patricio Escalante, MD, FCCP (Mayo Clinic, Rochester, MN); Stephen K. Field, MD (University of Calgary, Calgary, AB, Canada); Dina Fisher, MD, MSc (University of Calgary, Respiratory Medicine, Calgary, AB, Canada); Cynthia T. French, PhD, FCCP (UMass Memorial Medical Center, Worcester, MA); Cameron Grant, MB ChB, PhD (University of Aukland, New Zealand); Susan M. Harding, MD, FCCP (Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL); Anthony Harnden, MB ChB, MSc (University of Oxford, Oxford, England); Adam T. Hill, MB ChB, MD (Royal Infirmary and University of Edinburgh, Edinburgh, Scotland); Richard S. Irwin, MD, Master FCCP (UMass Memorial Medical Center, Worcester, MA); Vivek Iyer, MD, MPH Mayo Clinic, Rochester MN); Peter J. Kahrilas, MD (Feinberg School of Medicine, Northwestern University, Chicago, IL); Joanne Kavanagh, MBChB (Division of Asthma, Allergy and Lung Biology, King's College London); Denmark Hill, London, United Kingdom); Karina A. Keogh, MD (Mayo Clinic, Rochester, MN); Kefang Lai, MD, PhD (First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China); Andrew P. Lane, MD (Johns Hopkins University School of Medicine, Baltimore, MD); Kaiser Lim, MD (Mayo Clinic, Rochester, MN); J. Mark Madison, MD, FCCP (UMass Memorial Medical Center, Worcester, MA); Mark A. Malesker, PharmD, FCCP (Creighton University School of Pharmacy and Health Professions, Omaha, NE); Stuart Mazzone, PhD, FCCP (University of Melbourne, Victoria, Australia); Lorcan McGarvey, MD (The Queens University Belfast, Belfast, United Kingdom); Alex Molasoitis, PhD, RN (Hong Kong Polytechnic University, Hong Kong, China); Abigail Moore, BM BCh (University of Oxford, Oxford, England); M. Hassan Murad, MD, MPH (Mayo Clinic, Rochester, MN); Peter Newcombe, PhD (School of Psychology University of Queensland, QLD, Australia); John Oppenheimer, MD (UMDNJ-Rutgers University); Bruce Rubin, MEngr, MD (Virginia Commonwealth University, Richmond, VA); Richard J. Russell, MBBS (University of Leicester, Glenfield Hospital, Leicester, United Kingdom); Jay H. Ryu, MD, FCCP (Mayo Clinic, Rochester, MN); Sonal Singh, MD, MPH (UMass Memorial Medical Center, Worcester, MA); Jaclyn Smith, MB ChB, PhD (University of Manchester, Manchester, England); Susan M. Tarlo, MBBS, FCCP (Toronto Western Hospital, Toronto, ON, Canada); Anne E. Vertigan, PhD, BAppSc (SpPath) (John Hunter Hospital, NSW, Australia). Other contributions: We thank Nancy Harger, MLS, clinical service librarian who works in the University of Massachusetts Medical School Library, Worcester, MA, who undertook all the searches for this systematic review. Additional information: The e-Appendix and e-Table can be found in the Supplemental Materials section of the online article. FUNDING/SUPPORT: The authors have reported to CHEST that no funding was received for this study.