Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster; Susan L. Neuhausen; Jonathan Mangion; Yvette Quirk; Deborah Ford; Nadine Collins; Kim Nguyen; Sheila Seal; Thao Tran; Diane Averill; Patty Fields; Gill Marshall; Steven Narod; Gilbert M. Lenoir; Henry Lynch; Jean Feunteun; Peter Devilee; Cees J. Cornelisse; Fred H. Menko; Peter A. Daly; Wilma Ormiston; Ross McManus; Carole Pye; Cathryn M. Lewis; Lisa A. Cannon-Albright; Julian Peto; Bruce A.J. Ponder; Mark H. Skolnick; Douglas F. Easton; David E. Goldgar; Michael R. Stratton

doi:10.1126/science.8091231

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Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Journal article

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Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster, Susan L. Neuhausen, Jonathan Mangion, Yvette Quirk, Deborah Ford, Nadine Collins, Kim Nguyen, Sheila Seal, Thao Tran, Diane Averill, …

Science, Vol.265(5181), pp.2088-2090

265

09/30/1994

DOI: https://doi.org/10.1126/science.8091231

PMID: 8091231

Abstract

General

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

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Title: Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
Creators: Richard Wooster (Author) - Institute of Cancer Research
Susan L. Neuhausen (Author) - University of Utah
Jonathan Mangion (Author) - Institute of Cancer Research
Yvette Quirk (Author) - Institute of Cancer Research
Deborah Ford (Author) - Institute of Cancer Research
Nadine Collins (Author) - Institute of Cancer Research
Kim Nguyen (Author) - University of Utah
Sheila Seal (Author) - Institute of Cancer Research
Thao Tran (Author) - University of Utah
Diane Averill (Author) - Institute of Cancer Research
Patty Fields (Author) - University of Utah
Gill Marshall (Author) - Institute of Cancer Research
Steven Narod (Author) - McGill University
Gilbert M. Lenoir (Author) - International Agency for Research on Cancer
Henry Lynch (Author) - Creighton University
Jean Feunteun (Author) - Institut Gustave Roussy
Peter Devilee (Author) - Leiden University
Cees J. Cornelisse (Author) - Leiden University
Fred H. Menko (Author) - Vrije Universiteit Amsterdam
Peter A. Daly (Author) - Trinity College Dublin
Wilma Ormiston (Author) - Trinity College Dublin
Ross McManus (Author) - Trinity College Dublin
Carole Pye (Author) - University of Cambridge
Cathryn M. Lewis (Author) - University of Utah
Lisa A. Cannon-Albright (Author) - University of Utah
Julian Peto (Author) - Institute of Cancer Research
Bruce A.J. Ponder (Author) - University of Cambridge
Mark H. Skolnick (Author) - University of Utah
Douglas F. Easton (Author) - Institute of Cancer Research
David E. Goldgar (Author) - University of Utah
Michael R. Stratton (Author) - Institute of Cancer Research
Publication Details: Science, Vol.265(5181), pp.2088-2090
Series: 265
Number of pages: 3
Identifiers: 991005930470102656
Academic Unit: Creighton University
Language: English
Resource Type: Journal article

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

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