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Long-term outcome data from 121 patients treated with Gamma Knife stereotactic radiosurgery as salvage therapy for focally recurrent high-grade gliomas
Journal article   Peer reviewed

Long-term outcome data from 121 patients treated with Gamma Knife stereotactic radiosurgery as salvage therapy for focally recurrent high-grade gliomas

Cody J. Smith, Marshall J. Fairres, Charlotte S. Myers, Kristina M. Chapple, Michel Klysik, John P. Karis, Emad Youssef and Kris A. Smith
Journal of radiosurgery and SBRT, Vol.6(3), pp.199-207
01/01/2019
PMID: 31998540

Abstract

Life Sciences & Biomedicine Science & Technology Surgery
Introduction: We examined patient outcomes after Gamma Knife stereotactic radiosurgery (GKSRS) salvage therapy for recurrent high-grade gliomas (HGGs) to determine whether tumor grade or lesion size affected overall survival (OS) and progression-free survival (PFS). Methods: This single-center retrospective study assessed radiographic response and clinical outcomes following GKSRS salvage treatment of recurrent malignant gliomas (January 2005-March 2014). Results: A total of 121 patients (67 female) with 132 tumors were treated. Median (range) PFS was 4.7 (3.9-5.4) months for the cohort, 6.8 (4.6-8.9) months for initial grade 2 tumors, 4.2 (1.9-6.5) months for initial grade 3 tumors, and 4.3 (3.7-4.9) months for initial grade 4 tumors. Patients with small lesions (<= 6.7 cm(3); n = 53) had significantly longer median (range) PFS (6.8 [4.8-8.8], P=0.02). Conclusions: GKSRS offers meaningful salvage therapy with minimal morbidity in appropriately selected patients with focally recurrent HGGs.

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